GNE-3511 [Ligand Id: 9355] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3393333
  • mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
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  • mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
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  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
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  • mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
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  • mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
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  • mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779]
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  • mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
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  • mitogen-activated protein kinase kinase kinase 12/Mitogen-activated protein kinase kinase kinase 12 in Human [ChEMBL: CHEMBL1908389] [GtoPdb: 2072] [UniProtKB: Q12852]
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  • mitogen-activated protein kinase kinase kinase 13/Mitogen-activated protein kinase kinase kinase 13 in Human [ChEMBL: CHEMBL1163124] [GtoPdb: 2073] [UniProtKB: O43283]
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  • mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
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  • ribosomal protein S6 kinase B1 in Human [GtoPdb: 1525] [UniProtKB: P23443]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
ChEMBL Inhibition of JNK1 (unknown origin) B 6.89 pIC50 129 nM IC50 J Med Chem (2015) 58: 401-418 [PMID:25341110]
GtoPdb - - 6.89 pIC50 129 nM IC50 J Med Chem (2015) 58: 401-18 [PMID:25341110]
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL Inhibition of JNK2 (unknown origin) B 6.29 pIC50 514 nM IC50 J Med Chem (2015) 58: 401-418 [PMID:25341110]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL Inhibition of JNK3 (unknown origin) B 6.44 pIC50 364 nM IC50 J Med Chem (2015) 58: 401-418 [PMID:25341110]
GtoPdb - - 6.44 pIC50 364 nM IC50 J Med Chem (2015) 58: 401-18 [PMID:25341110]
mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
ChEMBL Inhibition of MKK4 (unknown origin) B 5.3 pIC50 >5000 nM IC50 J Med Chem (2015) 58: 401-418 [PMID:25341110]
mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
ChEMBL Inhibition of MKK7 (unknown origin) B 5.3 pIC50 >5000 nM IC50 J Med Chem (2015) 58: 401-418 [PMID:25341110]
mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779]
ChEMBL Inhibition of MLK2 (unknown origin) B 6.12 pIC50 767 nM IC50 J Med Chem (2015) 58: 401-418 [PMID:25341110]
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
ChEMBL Inhibition of MLK3 (unknown origin) B 6.22 pIC50 602 nM IC50 J Med Chem (2015) 58: 401-418 [PMID:25341110]
mitogen-activated protein kinase kinase kinase 12/Mitogen-activated protein kinase kinase kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908389] [GtoPdb: 2072] [UniProtKB: Q12852]
GtoPdb - - 9.3 pKi <0.5 nM Ki J Med Chem (2015) 58: 8182-99 [PMID:26431428]
ChEMBL Inhibition of DLK (unknown origin) B 9.3 pKi <0.5 nM Ki J Med Chem (2015) 58: 401-418 [PMID:25341110]
ChEMBL Inhibition of human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-based assay B 7.52 pIC50 30 nM IC50 J Med Chem (2015) 58: 401-418 [PMID:25341110]
ChEMBL Inhibition of DLK (unknown origin) B 8.52 pIC50 3 nM IC50 J Med Chem (2022) 65: 16290-16312 [PMID:36469401]
mitogen-activated protein kinase kinase kinase 13/Mitogen-activated protein kinase kinase kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163124] [GtoPdb: 2073] [UniProtKB: O43283]
GtoPdb - - 9.3 pKi <0.5 nM Ki J Med Chem (2015) 58: 401-18 [PMID:25341110]
ChEMBL Inhibition of LZK (unknown origin) B 8.52 pIC50 3 nM IC50 J Med Chem (2022) 65: 16290-16312 [PMID:36469401]
mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
ChEMBL Inhibition of MLK1 (unknown origin) B 7.17 pIC50 67.8 nM IC50 J Med Chem (2015) 58: 401-418 [PMID:25341110]
GtoPdb - - 7.17 pIC50 67.8 nM IC50 J Med Chem (2015) 58: 401-18 [PMID:25341110]
Protein delta homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5671] [UniProtKB: P80370]
ChEMBL Binding affinity to DLK (unknown origin) assessed as inhibition constant B 9.3 pKi <0.5 nM Ki Eur J Med Chem (2023) 255: 115404-115404 [PMID:37098296]
ribosomal protein S6 kinase B1 in Human [GtoPdb: 1525] [UniProtKB: P23443]
GtoPdb - - 5.71 pIC50 1940 nM IC50 J Med Chem (2007) 50: 6-9 [PMID:17201405]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]