benperidol [Ligand Id: 9215] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL297302 (Anquil, Benperidol, Benquil, MCN-JR-4584, NSC-170982, R-4584) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT2A receptor/5-hydroxytryptamine receptor 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Binding affinity to 5HT2A receptor (unknown origin) | B | 8.92 | pKi | 1.2 | nM | Ki | Bioorg Med Chem (2016) 24: 3671-3679 [PMID:27364609] |
| D2 receptor/D(2) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity to human dopamine D2 receptor by radioligand displacement assay | B | 10.57 | pKi | 0.03 | nM | Ki | Bioorg Med Chem (2016) 24: 3671-3679 [PMID:27364609] |
| GtoPdb | - | - | 10.57 | pKi | 0.03 | nM | Ki | Mol Psychiatry (1998) 3: 123-34 [PMID:9577836] |
| D3 receptor/D(3) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Displacement of [125I]-IABN from human recombinant dopamine D3 receptor expressed in HEK293 cell membrane incubated for 60 mins filtration binding assay | B | 9.54 | pKi | 0.29 | nM | Ki | Bioorg Med Chem (2016) 24: 3671-3679 [PMID:27364609] |
| D4 receptor/D(4) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| GtoPdb | - | - | 10.18 | pKi | 0.07 | nM | Ki | Mol Psychiatry (1998) 3: 123-34 [PMID:9577836] |
| ChEMBL | Binding affinity to human dopamine D4 receptor by radioligand displacement assay | B | 10.18 | pKi | 0.07 | nM | Ki | Bioorg Med Chem (2016) 24: 3671-3679 [PMID:27364609] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
