(S)-liquiritigenin [Ligand Id: 8899] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL252642 ((2S)-Liquiritigenin, 4',7-Dihydroxyflavanone, 7,4'-Dihydroxyflavanone, Liquiritigenin, Liquirtigenin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 to 20 mins by Ellman's method | B | 5.04 | pIC50 | 9100 | nM | IC50 | Bioorg Med Chem Lett (2021) 52: 128306-128306 [PMID:34371131] |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate incubated for 15 to 20 mins by Ellman's method | B | 4.85 | pIC50 | 14040 | nM | IC50 | Bioorg Med Chem Lett (2021) 52: 128306-128306 [PMID:34371131] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Inhibition of human aromatase in placental microsomes | B | 5.68 | pIC50 | 2100 | nM | IC50 | Bioorg Med Chem (2008) 16: 1474-1480 [PMID:18042388] |
| ChEMBL | Inhibition of human aromatase by fluorometric assay | B | 6.47 | pIC50 | 340 | nM | IC50 | Bioorg Med Chem (2008) 16: 8466-8470 [PMID:18778944] |
| Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] | ||||||||
| ChEMBL | Agonist activity at ER-beta (unknown origin) | B | 7.44 | pEC50 | 36.5 | nM | EC50 | Eur J Med Chem (2022) 241: 114658-114658 [PMID:35964426] |
| GtoPdb | Measuring activation of the ERE tk-Luc reporter by ER&bets; in transfected U2OS cells. | - | 7.44 | pEC50 | 36.5 | nM | EC50 | Mol Cell Endocrinol (2008) 283: 49-57 [PMID:18177995] |
| Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6135] [UniProtKB: B4URF0] | ||||||||
| ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assay | B | 5.08 | pIC50 | 8330 | nM | IC50 | J Nat Prod (2014) 77: 563-570 [PMID:24313801] |
| ChEMBL | Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assay | B | 5.68 | pIC50 | 2070 | nM | IC50 | J Nat Prod (2014) 77: 563-570 [PMID:24313801] |
| proteasome 20S subunit beta 5/Proteasome Macropain subunit MB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4662] [GtoPdb: 2406] [UniProtKB: P28074] | ||||||||
| ChEMBL | Inhibition of chymotrypsin-like activity of purified human erythrocyte 20S proteasome assessed as decrease in AMC hydrolysis using Suc-LLVY-AMC as substrate preincubated for 10 mins and measured by fluorescence based method | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2019) 167: 291-311 [PMID:30776692] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of human recombinant PTP1B assessed as p-nitorphenol production after 30 mins | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2011) 19: 3378-3383 [PMID:21571537] |
| ChEMBL | Inhibition of human recombinant PTP1B | B | 4.22 | pIC50 | >60000 | nM | IC50 | J Nat Prod (2006) 69: 1572-1576 [PMID:17125223] |
| ChEMBL | Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate after 30 mins | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5155-5157 [PMID:19632832] |
| YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
| ChEMBL | Inhibition of YES (unknown origin) | B | 4.95 | pIC50 | 11300 | nM | IC50 | Eur J Med Chem (2019) 166: 186-196 [PMID:30769179] |
| Xanthine dehydrogenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3649] [UniProtKB: P80457] | ||||||||
| ChEMBL | Inhibition of cow milk xanthine oxidase | B | 4.95 | pIC50 | 11300 | nM | IC50 | J Nat Prod (1988) 51: 345-348 [PMID:3379415] |
| TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6] | ||||||||
| GtoPdb | - | - | 5.2 | pIC50 | - | - | - | Mol Pharmacol (2013) 84: 736-50 [PMID:24006495] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
