Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1412853 |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
nucleotide binding oligomerization domain containing 1/Nucleotide-binding oligomerization domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293222] [GtoPdb: 1762] [UniProtKB: Q9Y239] | ||||||||
ChEMBL | Antagonist activity at human NOD1 expressed in HEK293 cells assessed as reduction in C12-iE-DAP-induced NF-kappaB activation preincubated for 1 hr followed by C12-iE-DAP stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis | B | 6.11 | pIC50 | 771 | nM | IC50 | Eur J Med Chem (2020) 190: 112089-112089 [PMID:32014680] |
GtoPdb | - | - | 6.25 | pIC50 | 560 | nM | IC50 | ACS Med Chem Lett (2011) 2: 780-785 [PMID:22003428] |
ChEMBL | Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay | B | 6.25 | pIC50 | 560 | nM | IC50 | ACS Med Chem Lett (2011) 2: 780-785 [PMID:22003428] |
ChEMBL | Inhibition of NOD1 (unknown origin) expressed in HEK293T cells coexpressing NF-kappaB driven luciferase reporter gene by HTS primary assay | B | 6.25 | pIC50 | 560 | nM | IC50 | J Med Chem (2014) 57: 6897-6918 [PMID:24707857] |
ChEMBL | Inhibition of human NOD1 over-expressed in HEK-Blue cells assessed as inhibition of C12-iE-DAP induced NF-kappaB transcriptional activity preincubated for 1 hr followed by addition of C12-iE-DAP measured after 18 hrs by SEAP reporter gene assay | B | 6.25 | pIC50 | 560 | nM | IC50 | Bioorg Med Chem (2016) 24: 5221-5234 [PMID:27601373] |
nucleotide binding oligomerization domain containing 2/Nucleotide-binding oligomerization domain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293266] [GtoPdb: 1763] [UniProtKB: Q9HC29] | ||||||||
ChEMBL | Inhibition of human NOD2 over-expressed in HEK-Blue cells assessed as inhibition of C12-iE-DAP induced NF-kappaB transcriptional activity preincubated for 1 hr followed by addition of C12-iE-DAP measured after 18 hrs by SEAP reporter gene assay | B | 4.26 | pIC50 | 54900 | nM | IC50 | Bioorg Med Chem (2016) 24: 5221-5234 [PMID:27601373] |
ChEMBL | Antagonist activity at human NOD2 expressed in HEK293 cells assessed as reduction in MDP-induced NF-kappaB activation preincubated for 1 hr followed by MDP stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis | B | 4.26 | pIC50 | 54900 | nM | IC50 | Eur J Med Chem (2020) 190: 112089-112089 [PMID:32014680] |
ChEMBL | Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 780-785 [PMID:22003428] |
ChEMBL | Inhibition of NOD2 (unknown origin) expressed in HEK293T cells coexpressing NF-kappaB driven luciferase reporter gene by HTS primary assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2014) 57: 6897-6918 [PMID:24707857] |
GtoPdb | - | - | 4.7 | pIC50 | >20000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 780-785 [PMID:22003428] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]