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nucleotide binding oligomerization domain containing 2

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Target id: 1763

Nomenclature: nucleotide binding oligomerization domain containing 2

Abbreviated Name: NOD2

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1040 16q12.1 NOD2 nucleotide binding oligomerization domain containing 2
Mouse - 1020 8 C3 Nod2 nucleotide-binding oligomerization domain containing 2
Rat - - 19p11 Nod2 nucleotide-binding oligomerization domain containing 2
Previous and Unofficial Names Click here for help
BLAU | CARD15 | CLR16.3 | IBD1 | PSORAS1 | caspase recruitment domain family, member 15 | NLR family, CARD domain containing 2 | NOD-like receptor C2 | NLRC2 | ACUG | NOD2B | CD | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 (NLRC2) | nucleotide-binding oligomerization domain containing 2
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ML130 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition <4.7 pIC50 1
pIC50 <4.7 (IC50 >2x10-5 M) [1]
Immunopharmacology Comments
NOD2 is an intracellular pattern recognition receptor that initiates an immune response to bacterial molecules containing muramyl dipeptide (MDP).

Mutations in NOD proteins are implicated in various inflammatory diseases associated with aberrant NF-κB activity; NF-κB being a major component of the signaling pathways involved in apoptosis, inflammation, and the immune response.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 14 GO processes
GO:0002221 pattern recognition receptor signaling pathway IDA
GO:0038187 pattern recognition receptor activity IDA
GO:0045087 innate immune response IDA
GO:0050727 regulation of inflammatory response IC
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
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GO:0002227 innate immune response in mucosa IEA
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA
GO:0006909 phagocytosis IEA
GO:0034134 toll-like receptor 2 signaling pathway IEA
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IEA
GO:0045089 positive regulation of innate immune response IEA
GO:0050766 positive regulation of phagocytosis IEA
GO:0090022 regulation of neutrophil chemotaxis IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0046645 positive regulation of gamma-delta T cell activation ISS
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GO:0002710 negative regulation of T cell mediated immunity IEA
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0050871 positive regulation of B cell activation IDA
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GO:0002710 negative regulation of T cell mediated immunity IEA
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 21 GO processes
GO:0002221 pattern recognition receptor signaling pathway IDA
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
GO:0002720 positive regulation of cytokine production involved in immune response IMP
GO:0002830 positive regulation of type 2 immune response IMP
GO:0046645 positive regulation of gamma-delta T cell activation ISS
GO:0050727 regulation of inflammatory response IC
GO:0050871 positive regulation of B cell activation IDA
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
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GO:0002253 activation of immune response IEA
GO:0002710 negative regulation of T cell mediated immunity IEA
GO:0002732 positive regulation of dendritic cell cytokine production IEA
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IEA
GO:0010936 negative regulation of macrophage cytokine production IEA
GO:0034134 toll-like receptor 2 signaling pathway IEA
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IEA
GO:0045089 positive regulation of innate immune response IEA
GO:0060907 positive regulation of macrophage cytokine production IEA
GO:0090022 regulation of neutrophil chemotaxis IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 19 GO processes
GO:0002720 positive regulation of cytokine production involved in immune response IMP
GO:0032731 positive regulation of interleukin-1 beta production IDA
GO:0032733 positive regulation of interleukin-10 production ISS
GO:0032740 positive regulation of interleukin-17 production IMP
GO:0032755 positive regulation of interleukin-6 production IDA
GO:0032757 positive regulation of interleukin-8 production IMP
GO:0032760 positive regulation of tumor necrosis factor production IDA
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
click arrow to show/hide IEA associations
GO:0002732 positive regulation of dendritic cell cytokine production IEA
GO:0010936 negative regulation of macrophage cytokine production IEA
GO:0032689 negative regulation of type II interferon production IEA
GO:0032695 negative regulation of interleukin-12 production IEA
GO:0032701 negative regulation of interleukin-18 production IEA
GO:0032703 negative regulation of interleukin-2 production IEA
GO:0032720 negative regulation of tumor necrosis factor production IEA
GO:0032735 positive regulation of interleukin-12 production IEA
GO:0060907 positive regulation of macrophage cytokine production IEA
GO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 3 GO processes
GO:0046645 positive regulation of gamma-delta T cell activation ISS
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GO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA
GO:0090022 regulation of neutrophil chemotaxis IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 7 GO processes
GO:0002221 pattern recognition receptor signaling pathway IDA
GO:0046645 positive regulation of gamma-delta T cell activation ISS
GO:0050871 positive regulation of B cell activation IDA
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
GO:1902523 positive regulation of protein K63-linked ubiquitination IMP
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GO:0034134 toll-like receptor 2 signaling pathway IEA
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IEA
Physiological Functions Comments
Pro-inflammatory, involved in autophagy.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Behcet syndrome
Synonyms: Behçet disease [Orphanet: ORPHA117]
Behcet's disease [Disease Ontology: DOID:13241]
Disease Ontology: DOID:13241
OMIM: 109650
Orphanet: ORPHA117
Disease:  Blau syndrome; BLAUS
Disease Ontology: DOID:0050678
OMIM: 186580
Orphanet: ORPHA90340
Disease:  Crohn's disease
Synonyms: Crohn disease [Disease Ontology: DOID:8778]
Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206
Disease:  Sarcoidosis, early-onset
Disease Ontology: DOID:11335
OMIM: 609464
Disease:  Ulcerative colitis
Synonyms: Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8577
OMIM: 266600
Orphanet: ORPHA771

References

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1. Khan PM, Correa RG, Divlianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Novo A et al.. (2011) Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. ACS Med Chem Lett, 2 (10): 780-785. [PMID:22003428]

Contributors

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