Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1040	16q12.1	NOD2	nucleotide binding oligomerization domain containing 2
Mouse	-	1020	8 C3	Nod2	nucleotide-binding oligomerization domain containing 2
Rat	-	-	19p11	Nod2	nucleotide-binding oligomerization domain containing 2

Previous and Unofficial Names

BLAU | CARD15 | CLR16.3 | IBD1 | PSORAS1 | caspase recruitment domain family, member 15 | NLR family, CARD domain containing 2 | NOD-like receptor C2 | NLRC2 | ACUG | NOD2B | CD | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 (NLRC2) | nucleotide-binding oligomerization domain containing 2

Database Links
Alphafold	Q9HC29 (Hs), Q8K3Z0 (Mm)
CATH/Gene3D	3.80.10.10
ChEMBL Target	CHEMBL1293266 (Hs)
Ensembl Gene	ENSG00000167207 (Hs), ENSMUSG00000055994 (Mm), ENSRNOG00000014124 (Rn)
Entrez Gene	64127 (Hs), 257632 (Mm), 291912 (Rn)
Human Protein Atlas	ENSG00000167207 (Hs)
KEGG Gene	hsa:64127 (Hs), mmu:257632 (Mm), rno:291912 (Rn)
OMIM	605956 (Hs)
Pharos	Q9HC29 (Hs)
UniProtKB	Q9HC29 (Hs), Q8K3Z0 (Mm)
Wikipedia	NOD2 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference ML130 Hs Inhibition <4.7 pIC50 1 ⤷ pIC50 <4.7 (IC50 >2x10-5 M) [1]

Immunopharmacology Comments

NOD2 is an intracellular pattern recognition receptor that initiates an immune response to bacterial molecules containing muramyl dipeptide (MDP). Mutations in NOD proteins are implicated in various inflammatory diseases associated with aberrant NF-κB activity; NF-κB being a major component of the signaling pathways involved in apoptosis, inflammation, and the immune response.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Antigen presentation

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Chemotaxis & migration

Immuno Process:  Cellular signalling

Physiological Functions Comments

Pro-inflammatory, involved in autophagy.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Behcet syndrome Synonyms: Behçet disease [Orphanet: ORPHA117] Behcet's disease [Disease Ontology: DOID:13241] Disease Ontology: DOID:13241 OMIM: 109650 Orphanet: ORPHA117
Disease:  Blau syndrome; BLAUS Disease Ontology: DOID:0050678 OMIM: 186580 Orphanet: ORPHA90340
Disease:  Crohn's disease Synonyms: Crohn disease [Disease Ontology: DOID:8778] Inflammatory bowel disease 1; IBD1 [OMIM: 266600] Disease Ontology: DOID:8778 OMIM: 266600 Orphanet: ORPHA206
Disease:  Sarcoidosis, early-onset Disease Ontology: DOID:11335 OMIM: 609464
Disease:  Ulcerative colitis Synonyms: Inflammatory bowel disease 1; IBD1 [OMIM: 266600] Disease Ontology: DOID:8577 OMIM: 266600 Orphanet: ORPHA771