Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1040	16q12.1	NOD2	nucleotide binding oligomerization domain containing 2
Mouse	-	1020	8 C3	Nod2	nucleotide-binding oligomerization domain containing 2
Rat	-	-	19p11	Nod2	nucleotide-binding oligomerization domain containing 2

Previous and Unofficial Names

BLAU | CARD15 | CLR16.3 | IBD1 | PSORAS1 | caspase recruitment domain family, member 15 | NLR family, CARD domain containing 2 | NOD-like receptor C2 | NLRC2 | ACUG | NOD2B | CD | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 (NLRC2) | nucleotide-binding oligomerization domain containing 2

Database Links
Alphafold	Q9HC29 (Hs), Q8K3Z0 (Mm)
CATH/Gene3D	3.80.10.10
ChEMBL Target	CHEMBL1293266 (Hs)
Ensembl Gene	ENSG00000167207 (Hs), ENSMUSG00000055994 (Mm), ENSRNOG00000014124 (Rn)
Entrez Gene	64127 (Hs), 257632 (Mm), 291912 (Rn)
Human Protein Atlas	ENSG00000167207 (Hs)
KEGG Gene	hsa:64127 (Hs), mmu:257632 (Mm), rno:291912 (Rn)
OMIM	605956 (Hs)
Pharos	Q9HC29 (Hs)
UniProtKB	Q9HC29 (Hs), Q8K3Z0 (Mm)
Wikipedia	NOD2 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference ML130 Hs Inhibition <4.7 pIC50 1 ⤷ pIC50 <4.7 (IC50 >2x10-5 M) [1]

Immunopharmacology Comments

NOD2 is an intracellular pattern recognition receptor that initiates an immune response to bacterial molecules containing muramyl dipeptide (MDP). Mutations in NOD proteins are implicated in various inflammatory diseases associated with aberrant NF-κB activity; NF-κB being a major component of the signaling pathways involved in apoptosis, inflammation, and the immune response.

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 14 GO processes GO:0002221 pattern recognition receptor signaling pathway IDA GO:0038187 pattern recognition receptor activity IDA GO:0045087 innate immune response IDA GO:0050727 regulation of inflammatory response IC GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA click arrow to show/hide IEA associations GO:0002227 innate immune response in mucosa IEA GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA GO:0006909 phagocytosis IEA GO:0034134 toll-like receptor 2 signaling pathway IEA GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IEA GO:0045089 positive regulation of innate immune response IEA GO:0050766 positive regulation of phagocytosis IEA GO:0090022 regulation of neutrophil chemotaxis IEA

Immuno Process:  Antigen presentation GO Annotations:  Associated to 1 GO processes GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS

Immuno Process:  T cell (activation) GO Annotations:  Associated to 3 GO processes GO:0046645 positive regulation of gamma-delta T cell activation ISS click arrow to show/hide IEA associations GO:0002710 negative regulation of T cell mediated immunity IEA GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 3 GO processes GO:0050871 positive regulation of B cell activation IDA click arrow to show/hide IEA associations GO:0002710 negative regulation of T cell mediated immunity IEA GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 21 GO processes GO:0002221 pattern recognition receptor signaling pathway IDA GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS GO:0002720 positive regulation of cytokine production involved in immune response IMP GO:0002830 positive regulation of type 2 immune response IMP GO:0046645 positive regulation of gamma-delta T cell activation ISS GO:0050727 regulation of inflammatory response IC GO:0050871 positive regulation of B cell activation IDA GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA click arrow to show/hide IEA associations GO:0002253 activation of immune response IEA GO:0002710 negative regulation of T cell mediated immunity IEA GO:0002732 positive regulation of dendritic cell cytokine production IEA GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IEA GO:0010936 negative regulation of macrophage cytokine production IEA GO:0034134 toll-like receptor 2 signaling pathway IEA GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IEA GO:0045089 positive regulation of innate immune response IEA GO:0060907 positive regulation of macrophage cytokine production IEA GO:0090022 regulation of neutrophil chemotaxis IEA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 19 GO processes GO:0002720 positive regulation of cytokine production involved in immune response IMP GO:0032731 positive regulation of interleukin-1 beta production IDA GO:0032733 positive regulation of interleukin-10 production ISS GO:0032740 positive regulation of interleukin-17 production IMP GO:0032755 positive regulation of interleukin-6 production IDA GO:0032757 positive regulation of interleukin-8 production IMP GO:0032760 positive regulation of tumor necrosis factor production IDA GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA click arrow to show/hide IEA associations GO:0002732 positive regulation of dendritic cell cytokine production IEA GO:0010936 negative regulation of macrophage cytokine production IEA GO:0032689 negative regulation of type II interferon production IEA GO:0032695 negative regulation of interleukin-12 production IEA GO:0032701 negative regulation of interleukin-18 production IEA GO:0032703 negative regulation of interleukin-2 production IEA GO:0032720 negative regulation of tumor necrosis factor production IEA GO:0032735 positive regulation of interleukin-12 production IEA GO:0060907 positive regulation of macrophage cytokine production IEA GO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 3 GO processes GO:0046645 positive regulation of gamma-delta T cell activation ISS click arrow to show/hide IEA associations GO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA GO:0090022 regulation of neutrophil chemotaxis IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 7 GO processes GO:0002221 pattern recognition receptor signaling pathway IDA GO:0046645 positive regulation of gamma-delta T cell activation ISS GO:0050871 positive regulation of B cell activation IDA GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA GO:1902523 positive regulation of protein K63-linked ubiquitination IMP click arrow to show/hide IEA associations GO:0034134 toll-like receptor 2 signaling pathway IEA GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IEA

Physiological Functions Comments

Pro-inflammatory, involved in autophagy.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Behcet syndrome Synonyms: Behçet disease [Orphanet: ORPHA117] Behcet's disease [Disease Ontology: DOID:13241] Disease Ontology: DOID:13241 OMIM: 109650 Orphanet: ORPHA117
Disease:  Blau syndrome; BLAUS Disease Ontology: DOID:0050678 OMIM: 186580 Orphanet: ORPHA90340
Disease:  Crohn's disease Synonyms: Crohn disease [Disease Ontology: DOID:8778] Inflammatory bowel disease 1; IBD1 [OMIM: 266600] Disease Ontology: DOID:8778 OMIM: 266600 Orphanet: ORPHA206
Disease:  Sarcoidosis, early-onset Disease Ontology: DOID:11335 OMIM: 609464
Disease:  Ulcerative colitis Synonyms: Inflammatory bowel disease 1; IBD1 [OMIM: 266600] Disease Ontology: DOID:8577 OMIM: 266600 Orphanet: ORPHA771