ChEMBL ligand: CHEMBL513136
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
GPR183/G-protein coupled receptor 183 in Human [ChEMBL: CHEMBL3259470] [GtoPdb: 81] [UniProtKB: P32249] There should be some charts here, you may need to enable JavaScript!
H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
NOP receptor/Nociceptin receptor in Human [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] NOP receptor in Mouse [GtoPdb: 320] [UniProtKB: P35377] NOP receptor in Rat [GtoPdb: 320] [UniProtKB: P35370] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb	Radioligand binding assay	-	5.54	pKi	2854	nM	Ki	J Pharmacol Exp Ther (2008) 326: 672-82 [PMID:18492950]
ChEMBL	Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cells	B	5.54	pKi	2854	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2519-2523 [PMID:19339177]
GPR183/G-protein coupled receptor 183 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259470] [GtoPdb: 81] [UniProtKB: P32249]
ChEMBL	GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR183	F	5.17	pIC50	6769	nM	IC50	EUbOPEN Chemogenomics Library - GPCR Dose-Respose
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL	PDSP Secondary Binding target: HRH2 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.	B	5.57	pKi	2670.85	nM	Ki	EUbOPEN Chemogenomics Library - PDSP Secondary Binding
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb	Radioligand binding assay	-	6.88	pKi	131	nM	Ki	J Pharmacol Exp Ther (2008) 326: 672-82 [PMID:18492950]
ChEMBL	Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cells	B	6.88	pKi	131	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2519-2523 [PMID:19339177]
ChEMBL	PDSP Secondary Binding target: OPRK1 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.	B	7.12	pKi	76.12	nM	Ki	EUbOPEN Chemogenomics Library - PDSP Secondary Binding
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	PDSP Secondary Binding target: OPRM1 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.	B	6.49	pKi	321	nM	Ki	EUbOPEN Chemogenomics Library - PDSP Secondary Binding
ChEMBL	Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cells	B	7.19	pKi	65	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2519-2523 [PMID:19339177]
GtoPdb	Radioligand binding assay	-	7.19	pKi	65	nM	Ki	J Pharmacol Exp Ther (2008) 326: 672-82 [PMID:18492950]
ChEMBL	Agonist activity at human mu opioid assessed as stimulation of GDP-induced [35S]GTPgammaS binding	F	6.16	pEC50	693	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2519-2523 [PMID:19339177]
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146]
GtoPdb	Radioligand binding assay	-	9.52	pKi	0.3	nM	Ki	J Pharmacol Exp Ther (2008) 326: 672-82 [PMID:18492950]
ChEMBL	Displacement of [125I][Tyr14]nociceptin from human cloned NOP receptor expressed in CHO cells	B	9.52	pKi	0.3	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2519-2523 [PMID:19339177]
GtoPdb	Stimulation of GTP-γ35S binding	-	7.92	pEC50	12	nM	EC50	J Pharmacol Exp Ther (2008) 326: 672-82 [PMID:18492950]
ChEMBL	Agonist activity at human NOP assessed as stimulation of GDP-induced [35S]GTPgammaS binding	F	7.92	pEC50	12	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2519-2523 [PMID:19339177]
NOP receptor in Mouse [GtoPdb: 320] [UniProtKB: P35377]
GtoPdb	Radioligand binding assay	-	8.94	pKi	1.15	nM	Ki	J Pharmacol Exp Ther (2008) 326: 672-82 [PMID:18492950]
NOP receptor in Rat [GtoPdb: 320] [UniProtKB: P35370]
GtoPdb	Radioligand binding assay	-	9.38	pKi	0.42	nM	Ki	J Pharmacol Exp Ther (2008) 326: 672-82 [PMID:18492950]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]