ChEMBL ligand: CHEMBL2158866
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] There should be some charts here, you may need to enable JavaScript!
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] There should be some charts here, you may need to enable JavaScript!
SMG1 nonsense mediated mRNA decay associated PI3K related kinase/Serine/threonine-protein kinase SMG1 in Human [ChEMBL: CHEMBL1795195] [GtoPdb: 2201] [UniProtKB: Q96Q15] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL	Inhibition of CDK1	B	4.49	pIC50	32000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of CDK2	B	5.15	pIC50	7100	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL	Inhibition of GSK3alpha	B	6.59	pIC50	260	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of GSK3beta	B	6.48	pIC50	330	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL	Inhibition of PI3Kalpha using diC8-tagged PIP2 as substrate after 30 to 60 mins by TAMRA-based fluorescence polarization assay	B	7.04	pIC50	92	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994]
GtoPdb	-	-	7.04	pIC50	92	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-41 [PMID:23021994]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
GtoPdb	-	-	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-41 [PMID:23021994]
ChEMBL	Inhibition of PI3Kgamma using diC8-tagged PIP2 as substrate after 30 to 60 mins by TAMRA-based fluorescence polarization assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994]
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
GtoPdb	-	-	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-41 [PMID:23021994]
ChEMBL	Inhibition of mTOR	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994]
SMG1 nonsense mediated mRNA decay associated PI3K related kinase/Serine/threonine-protein kinase SMG1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795195] [GtoPdb: 2201] [UniProtKB: Q96Q15]
ChEMBL	Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assay	B	9.96	pIC50	0.11	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994]
GtoPdb	-	-	9.96	pIC50	0.11	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6636-41 [PMID:23021994]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]