compound 53 [PMID: 19631533] [Ligand Id: 8811] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL567470 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 11A/Phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9] | ||||||||
| ChEMBL | Inhibition of PDE11 | B | 7.19 | pIC50 | 64.1 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 1A/Phosphodiesterase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750] | ||||||||
| ChEMBL | Inhibition of PDE1A | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 1B/Phosphodiesterase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064] | ||||||||
| ChEMBL | Inhibition of PDE1B | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 1C/Phosphodiesterase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4619] [GtoPdb: 1296] [UniProtKB: Q14123] | ||||||||
| ChEMBL | Inhibition of PDE1C | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] | ||||||||
| ChEMBL | Inhibition of PDE2 | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432] | ||||||||
| ChEMBL | Inhibition of PDE3A | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 3B/Phosphodiesterase 3B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370] | ||||||||
| ChEMBL | Inhibition of PDE3B | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] | ||||||||
| ChEMBL | Inhibition of PDE4A | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] | ||||||||
| ChEMBL | Inhibition of PDE4B | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| ChEMBL | Inhibition of PDE4B | B | 6.54 | pIC50 | 290 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] | ||||||||
| ChEMBL | Inhibition of PDE4C | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] | ||||||||
| ChEMBL | Inhibition of PDE4D | B | 5.92 | pIC50 | 1210 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] | ||||||||
| GtoPdb | - | - | 10.3 | pIC50 | 0.05 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-13 [PMID:19631533] |
| ChEMBL | Inhibition of PDE5 | B | 10.3 | pIC50 | 0.05 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 6A/Phosphodiesterase 6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3878] [GtoPdb: 1312] [UniProtKB: P16499] | ||||||||
| ChEMBL | Inhibition of PDE6 | B | 8.01 | pIC50 | 9.8 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| GtoPdb | - | - | 8.01 | pIC50 | 9.8 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-13 [PMID:19631533] |
| phosphodiesterase 7A/Phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946] | ||||||||
| ChEMBL | Inhibition of PDE7A | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 7B/Phosphodiesterase 7B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4716] [GtoPdb: 1306] [UniProtKB: Q9NP56] | ||||||||
| ChEMBL | Inhibition of PDE7B | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 8A/Phosphodiesterase 8A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658] | ||||||||
| ChEMBL | Inhibition of PDE8A | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 8B/Phosphodiesterase 8B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4408] [GtoPdb: 1308] [UniProtKB: O95263] | ||||||||
| ChEMBL | Inhibition of PDE8B | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 9A/Phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083] | ||||||||
| ChEMBL | Inhibition of PDE9 | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
