compound 53 [PMID: 19631533] [Ligand Id: 8811] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL567470
  • phosphodiesterase 11A/Phosphodiesterase 11A in Human [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 11ApKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • phosphodiesterase 1A/Phosphodiesterase 1A in Human [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 1ApKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 1B/Phosphodiesterase 1B in Human [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 1BpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 1C/Phosphodiesterase 1C in Human [ChEMBL: CHEMBL4619] [GtoPdb: 1296] [UniProtKB: Q14123]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 1CpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 2A/Phosphodiesterase 2A in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 2ApKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 3A/Phosphodiesterase 3A in Human [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 3ApKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 3B/Phosphodiesterase 3B in Human [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 3BpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 4ApKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 4BpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • phosphodiesterase 4C/Phosphodiesterase 4C in Human [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 4CpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 4DpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 5ApKd HumanpKi HumanpIC50 HumanpEC50 Human024681012Highcharts.com
  • phosphodiesterase 6A/Phosphodiesterase 6A in Human [ChEMBL: CHEMBL3878] [GtoPdb: 1312] [UniProtKB: P16499]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 6ApKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • phosphodiesterase 7A/Phosphodiesterase 7A in Human [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 7ApKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 7B/Phosphodiesterase 7B in Human [ChEMBL: CHEMBL4716] [GtoPdb: 1306] [UniProtKB: Q9NP56]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 7BpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 8A/Phosphodiesterase 8A in Human [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 8ApKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 8B/Phosphodiesterase 8B in Human [ChEMBL: CHEMBL4408] [GtoPdb: 1308] [UniProtKB: O95263]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 8BpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphodiesterase 9A/Phosphodiesterase 9A in Human [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
Created with Highcharts 10.3.3ValuesChart context menuPhosphodiesterase 9ApKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphodiesterase 11A/Phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
ChEMBL Inhibition of PDE11 B 7.19 pIC50 64.1 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 1A/Phosphodiesterase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750]
ChEMBL Inhibition of PDE1A B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 1B/Phosphodiesterase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064]
ChEMBL Inhibition of PDE1B B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 1C/Phosphodiesterase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4619] [GtoPdb: 1296] [UniProtKB: Q14123]
ChEMBL Inhibition of PDE1C B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL Inhibition of PDE2 B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
ChEMBL Inhibition of PDE3A B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 3B/Phosphodiesterase 3B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370]
ChEMBL Inhibition of PDE3B B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL Inhibition of PDE4A B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL Inhibition of PDE4B B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
ChEMBL Inhibition of PDE4B B 6.54 pIC50 290 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
ChEMBL Inhibition of PDE4C B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL Inhibition of PDE4D B 5.92 pIC50 1210 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
GtoPdb - - 10.3 pIC50 0.05 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-13 [PMID:19631533]
ChEMBL Inhibition of PDE5 B 10.3 pIC50 0.05 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 6A/Phosphodiesterase 6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3878] [GtoPdb: 1312] [UniProtKB: P16499]
ChEMBL Inhibition of PDE6 B 8.01 pIC50 9.8 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
GtoPdb - - 8.01 pIC50 9.8 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-13 [PMID:19631533]
phosphodiesterase 7A/Phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
ChEMBL Inhibition of PDE7A B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 7B/Phosphodiesterase 7B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4716] [GtoPdb: 1306] [UniProtKB: Q9NP56]
ChEMBL Inhibition of PDE7B B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 8A/Phosphodiesterase 8A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658]
ChEMBL Inhibition of PDE8A B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 8B/Phosphodiesterase 8B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4408] [GtoPdb: 1308] [UniProtKB: O95263]
ChEMBL Inhibition of PDE8B B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 9A/Phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
ChEMBL Inhibition of PDE9 B 5.7 pIC50 >2000 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]