compound 69 [PMID: 19136975] [Ligand Id: 8782] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL492572
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PLD1/Phospholipase D1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2536] [GtoPdb: 1433] [UniProtKB: Q13393]
ChEMBL Inhibition of human PLD1 in Calu1 cells B 7.34 pIC50 46 nM IC50 Bioorg Med Chem Lett (2009) 19: 1916-1920 [PMID:19268584]
ChEMBL Inhibition of human PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 7.34 pIC50 46 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
GtoPdb - - 7.34 pIC50 46 nM IC50 Nat Chem Biol (2009) 5: 108-17 [PMID:19136975]
ChEMBL Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis B 7.96 pIC50 11 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
ChEMBL Inhibition of PLD1 in human calu1 cells B 7.96 pIC50 11 nM IC50 J Med Chem (2010) 53: 6706-6719 [PMID:20735042]
PLD1/Phospholipase D1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308939] [GtoPdb: 1433] [UniProtKB: P70496]
ChEMBL Inhibition of N-terminally truncated rat PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 6.48 pIC50 331 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
PLD2/Phospholipase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2734] [GtoPdb: 1434] [UniProtKB: O14939]
ChEMBL Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis B 5.74 pIC50 1800 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
ChEMBL Inhibition of human GST-tagged PLD2A in human HEK293 cells B 5.74 pIC50 1800 nM IC50 J Med Chem (2010) 53: 6706-6719 [PMID:20735042]
GtoPdb - - 6.03 pIC50 933 nM IC50 Nat Chem Biol (2009) 5: 108-17 [PMID:19136975]
ChEMBL Inhibition of GFP-labelled human PLD2 HEK293 cells B 6.03 pIC50 933 nM IC50 Bioorg Med Chem Lett (2009) 19: 1916-1920 [PMID:19268584]
ChEMBL Inhibition of human PLD2 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 6.03 pIC50 933 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]