compound 69 [PMID: 19136975] [Ligand Id: 8782] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL492572 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| PLD1/Phospholipase D1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2536] [GtoPdb: 1433] [UniProtKB: Q13393] | ||||||||
| ChEMBL | Inhibition of human PLD1 in Calu1 cells | B | 7.34 | pIC50 | 46 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1916-1920 [PMID:19268584] |
| ChEMBL | Inhibition of human PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | B | 7.34 | pIC50 | 46 | nM | IC50 | Nat Chem Biol (2009) 5: 108-117 [PMID:19136975] |
| GtoPdb | - | - | 7.34 | pIC50 | 46 | nM | IC50 | Nat Chem Biol (2009) 5: 108-17 [PMID:19136975] |
| ChEMBL | Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis | B | 7.96 | pIC50 | 11 | nM | IC50 | Nat Chem Biol (2009) 5: 108-117 [PMID:19136975] |
| ChEMBL | Inhibition of PLD1 in human calu1 cells | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2010) 53: 6706-6719 [PMID:20735042] |
| PLD1/Phospholipase D1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308939] [GtoPdb: 1433] [UniProtKB: P70496] | ||||||||
| ChEMBL | Inhibition of N-terminally truncated rat PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | B | 6.48 | pIC50 | 331 | nM | IC50 | Nat Chem Biol (2009) 5: 108-117 [PMID:19136975] |
| PLD2/Phospholipase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2734] [GtoPdb: 1434] [UniProtKB: O14939] | ||||||||
| ChEMBL | Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis | B | 5.74 | pIC50 | 1800 | nM | IC50 | Nat Chem Biol (2009) 5: 108-117 [PMID:19136975] |
| ChEMBL | Inhibition of human GST-tagged PLD2A in human HEK293 cells | B | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2010) 53: 6706-6719 [PMID:20735042] |
| GtoPdb | - | - | 6.03 | pIC50 | 933 | nM | IC50 | Nat Chem Biol (2009) 5: 108-17 [PMID:19136975] |
| ChEMBL | Inhibition of GFP-labelled human PLD2 HEK293 cells | B | 6.03 | pIC50 | 933 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1916-1920 [PMID:19268584] |
| ChEMBL | Inhibition of human PLD2 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | B | 6.03 | pIC50 | 933 | nM | IC50 | Nat Chem Biol (2009) 5: 108-117 [PMID:19136975] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
