compound 69 [PMID: 19136975] [Ligand Id: 8782] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL492572 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| PLD1/Phospholipase D1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2536] [GtoPdb: 1433] [UniProtKB: Q13393] | ||||||||
| ChEMBL | Inhibition of human PLD1 in Calu1 cells | B | 7.34 | pIC50 | 46 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1916-1920 [PMID:19268584] |
| ChEMBL | Inhibition of human PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | B | 7.34 | pIC50 | 46 | nM | IC50 | Nat Chem Biol (2009) 5: 108-117 [PMID:19136975] |
| GtoPdb | - | - | 7.34 | pIC50 | 46 | nM | IC50 | Nat Chem Biol (2009) 5: 108-17 [PMID:19136975] |
| ChEMBL | Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis | B | 7.96 | pIC50 | 11 | nM | IC50 | Nat Chem Biol (2009) 5: 108-117 [PMID:19136975] |
| ChEMBL | Inhibition of PLD1 in human calu1 cells | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2010) 53: 6706-6719 [PMID:20735042] |
| PLD1/Phospholipase D1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308939] [GtoPdb: 1433] [UniProtKB: P70496] | ||||||||
| ChEMBL | Inhibition of N-terminally truncated rat PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | B | 6.48 | pIC50 | 331 | nM | IC50 | Nat Chem Biol (2009) 5: 108-117 [PMID:19136975] |
| PLD2/Phospholipase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2734] [GtoPdb: 1434] [UniProtKB: O14939] | ||||||||
| ChEMBL | Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis | B | 5.74 | pIC50 | 1800 | nM | IC50 | Nat Chem Biol (2009) 5: 108-117 [PMID:19136975] |
| ChEMBL | Inhibition of human GST-tagged PLD2A in human HEK293 cells | B | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2010) 53: 6706-6719 [PMID:20735042] |
| GtoPdb | - | - | 6.03 | pIC50 | 933 | nM | IC50 | Nat Chem Biol (2009) 5: 108-17 [PMID:19136975] |
| ChEMBL | Inhibition of GFP-labelled human PLD2 HEK293 cells | B | 6.03 | pIC50 | 933 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1916-1920 [PMID:19268584] |
| ChEMBL | Inhibition of human PLD2 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | B | 6.03 | pIC50 | 933 | nM | IC50 | Nat Chem Biol (2009) 5: 108-117 [PMID:19136975] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
