FIPI [Ligand Id: 8781] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL398567
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PLD1/Phospholipase D1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2536] [GtoPdb: 1433] [UniProtKB: Q13393]
GtoPdb - - 8.02 pIC50 9.5 nM IC50 Nat Chem Biol (2009) 5: 108-17 [PMID:19136975]
ChEMBL Inhibition of human PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 8.02 pIC50 9.5 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
ChEMBL Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis B 9 pIC50 1 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
PLD1/Phospholipase D1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308939] [GtoPdb: 1433] [UniProtKB: P70496]
ChEMBL Inhibition of N-terminally truncated rat PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 7.48 pIC50 33 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
PLD2/Phospholipase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2734] [GtoPdb: 1434] [UniProtKB: O14939]
ChEMBL Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis B 6.52 pIC50 300 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
ChEMBL Inhibition of PLD2 B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2007) 17: 2310-2311 [PMID:17317170]
ChEMBL Inhibition of human PLD2 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 7.77 pIC50 17 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
GtoPdb - - 7.77 pIC50 17 nM IC50 Nat Chem Biol (2009) 5: 108-17 [PMID:19136975]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]