ChEMBL ligand: CHEMBL1939914
phosphodiesterase 10A/Phosphodiesterase 10A in Human [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 11A/Phosphodiesterase 11A in Human [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 1A/Phosphodiesterase 1A in Human [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 2A/Phosphodiesterase 2A in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3A/Phosphodiesterase 3A in Human [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 7A/Phosphodiesterase 7A in Human [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 8A/Phosphodiesterase 8A in Human [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 9A/Phosphodiesterase 9A in Human [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 10A/Phosphodiesterase 10A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233]
GtoPdb	-	-	9	pKi	1	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-9 [PMID:22142545]
ChEMBL	Displacement of [3H]cAMP from human recombinant PDE10A1 by competitive binding assay	B	9	pKi	1	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 11A/Phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
ChEMBL	Displacement of [3H]cAMP from PDE11A3 by competitive binding assay	B	4.84	pKi	14600	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 1A/Phosphodiesterase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750]
ChEMBL	Displacement of [3H]cAMP from PDE1A3 by competitive binding assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL	Displacement of [3H]cAMP from PDE2A by competitive binding assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
ChEMBL	Displacement of [3H]cAMP from PDE3A by competitive binding assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Displacement of [3H]cAMP from PDE4B2 by competitive binding assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL	Displacement of [3H]cAMP from PDE5A1 by competitive binding assay	B	4.97	pKi	10600	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 7A/Phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
ChEMBL	Displacement of [3H]cAMP from PDE7A1 by competitive binding assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 8A/Phosphodiesterase 8A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658]
ChEMBL	Displacement of [3H]cAMP from PDE8A1 by competitive binding assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 9A/Phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
ChEMBL	Displacement of [3H]cAMP from PDE9A1 by competitive binding assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]