tipiracil [Ligand Id: 8696] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL235668 (MA-1, Tipiracil, TPI (freebase)) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Thymidine phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3106] [UniProtKB: P19971] | ||||||||
| ChEMBL | Competitive inhibition of thymidine phosphorylase (unknown origin) | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2019) 62: 1231-1245 [PMID:30615449] |
| ChEMBL | Inhibitory activity against human thymidine phosphorylase | B | 7.77 | pKi | 17 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 3705-3709 [PMID:14552762] |
| ChEMBL | Binding affinity towards recombinant thymidine phosphorylase TP | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 107-110 [PMID:12467627] |
| ChEMBL | Inhibition of human placental thymidine phosphorylase | B | 8.68 | pKi | 2.1 | nM | Ki | J Med Chem (2007) 50: 6016-6023 [PMID:17963370] |
| ChEMBL | Inhibition of human recombinant thymidine phosphorylase expressed in V79 cells | B | 8.89 | pKi | 1.3 | nM | Ki | J Med Chem (2007) 50: 6016-6023 [PMID:17963370] |
| ChEMBL | Inhibitory concentration against human thymidine phosphorylase TP | B | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 107-110 [PMID:12467627] |
| ChEMBL | Inhibition of thymidine phosphorylase (unknown origin) | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2019) 62: 1231-1245 [PMID:30615449] |
| ChEMBL | Inhibitory activity against Escherichia coli thymidine phosphorylase | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3705-3709 [PMID:14552762] |
| Thymidine phosphorylase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3726] [UniProtKB: P07650] | ||||||||
| ChEMBL | Inhibition of Escherichia coli thymidine phosphorylase | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 1648-1651 [PMID:20138520] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
