- Guide to PHARMACOLOGY
Synonyms: MA-1 | TAS-1-462
tipiracil is an approved drug (Japan only)
Compound class: Synthetic organic
Comment: Tipracil is a a uracil derivative that inhibits thymidine phosphorylase (TYMP, P19971; a.k.a. platelet-derived endothelial cell growth factor), an enzyme which metabolises trifluridine.
TAS-102 contains tipracil as the hydrochloride salt (PubChem CID 9903778).
SARS-CoV-2: Tipracil has been shown to bind to the uridine-specific endoribonuclease Nsp15 of SARS-CoV-2, and this interaction inhibits the enzyme's uridine-degrading catalytic activity .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|Approved drug?||Yes (Japan only)|
|International Nonproprietary Names|
|MA-1 | TAS-1-462|
|CAS Registry No.||183204-74-2 (source: PubChem)|
|GtoPdb PubChem SID||252166896|
|Search Google for chemical match using the InChIKey||QQHMKNYGKVVGCZ-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||QQHMKNYGKVVGCZ|
|Search PubMed clinical trials||tipiracil|
|Search PubMed titles||tipiracil|
|Search PubMed titles/abstracts||tipiracil|
|UniChem Compound Search for chemical match using the InChIKey||QQHMKNYGKVVGCZ-UHFFFAOYSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||QQHMKNYGKVVGCZ-UHFFFAOYSA-N|