ABT-670 [Ligand Id: 8439] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL219182 (ABT-670) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Displacement of [125I]7-OH-PIPAT from human D2L receptor expressed in HEK293 cell membrane | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| ChEMBL | Binding affinity to human D2S receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| GtoPdb | - | - | 5.84 | pKi | 1445 | nM | Ki | J Med Chem (2006) 49: 7450-65 [PMID:17149874] |
| ChEMBL | Displacement of [3H]A369508 from human D4 receptor expressed in HEK293 cell membrane | B | 5.84 | pKi | 1445 | nM | Ki | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| ChEMBL | Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR | F | 7.05 | pEC50 | 89 | nM | EC50 | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| D4 receptor/Dopamine D4 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3361] [GtoPdb: 217] [UniProtKB: P30729] | ||||||||
| ChEMBL | Agonist activity at rat D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR | F | 7.03 | pEC50 | 93 | nM | EC50 | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
