ChEMBL ligand: CHEMBL522691
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] There should be some charts here, you may need to enable JavaScript!
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] Serotonin 7 (5-HT7) receptor in Guinea pig [ChEMBL: CHEMBL5494] [UniProtKB: P50407] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Binding affinity to dopamine D2 receptor (unknown origin)	B	6.62	pKi	242	nM	Ki	Eur J Med Chem (2016) 120: 363-379 [PMID:27318552]
ChEMBL	Displacement of [3H]spiroperidol from human cloned dopamine D2L receptor expressed in rat C6 cells	B	6.85	pKi	142	nM	Ki	J. Med. Chem. (2008) 51: 5813-5822 [PMID:18800769]
ChEMBL	Displacement of [3H]-raclopride from recombinant human D2 receptor expressed in cell membrane measured after 1.5 hrs by scintillation counting method	B	6.85	pKi	142	nM	Ki	MedChemComm (2018) 9: 1882-1890 [PMID:30568756]
GtoPdb	-	-	6.85	pKi	142	nM	Ki	J Med Chem (2008) 51: 5813-22 [PMID:18800769]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Displacement of [3H]8-OH-DPAT from human 5HT1A receptor transfected in HEK293-EBNA cells after 120 mins	B	6.42	pKi	379	nM	Ki	Bioorg. Med. Chem. (2014) 22: 1736-1750 [PMID:24508140]
ChEMBL	Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor after 1.5 hrs	B	6.42	pKi	379	nM	Ki	Bioorg. Med. Chem. Lett. (2013) 23: 6083-6086 [PMID:24100077]
ChEMBL	Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor after 1.5 hrs by cell based assay	B	6.42	pKi	379	nM	Ki	Eur J Med Chem (2016) 120: 363-379 [PMID:27318552]
ChEMBL	Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in HEK293 cells	B	6.73	pKi	188	nM	Ki	J. Med. Chem. (2008) 51: 5813-5822 [PMID:18800769]
ChEMBL	Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr by beta-counting	B	6.73	pKi	188	nM	Ki	Eur. J. Med. Chem. (2014) 78: 10-22 [PMID:24675176]
ChEMBL	Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr	B	6.73	pKi	188	nM	Ki	Eur. J. Med. Chem. (2012) 56: 348-360 [PMID:22926225]
ChEMBL	Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	B	6.73	pKi	188	nM	Ki	MedChemComm (2018) 9: 1882-1890 [PMID:30568756]
GtoPdb	-	-	6.73	pKi	188	nM	Ki	J Med Chem (2008) 51: 5813-22 [PMID:18800769]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL	Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	B	6.2	pKi	626	nM	Ki	MedChemComm (2018) 9: 1882-1890 [PMID:30568756]
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
ChEMBL	Displacement of [3H]LSD from human recombinant 5-HT5A receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	B	6.75	pKi	178	nM	Ki	MedChemComm (2018) 9: 1882-1890 [PMID:30568756]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL	Displacement of [3H]-LSD from human 5-HT6 receptor after 1.5 hrs by cell based assay	B	5.8	pKi	1571	nM	Ki	Eur J Med Chem (2016) 120: 363-379 [PMID:27318552]
ChEMBL	Displacement of [3H]LSD from human recombinant 5-HT6 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	B	5.8	pKi	1571	nM	Ki	MedChemComm (2018) 9: 1882-1890 [PMID:30568756]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	B	7.82	pKi	15	nM	Ki	Bioorg. Med. Chem. (2014) 22: 1736-1750 [PMID:24508140]
ChEMBL	Displacement of [3H]-5-CT from human cloned 5HT7 receptor	B	7.82	pKi	15	nM	Ki	J. Med. Chem. (2012) 55: 6375-6380 [PMID:22738316]
ChEMBL	Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs	B	7.82	pKi	15	nM	Ki	Bioorg. Med. Chem. Lett. (2013) 23: 6083-6086 [PMID:24100077]
ChEMBL	Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay	B	7.82	pKi	15	nM	Ki	Eur J Med Chem (2016) 120: 363-379 [PMID:27318552]
ChEMBL	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	B	9.22	pKi	0.6	nM	Ki	MedChemComm (2018) 9: 1882-1890 [PMID:30568756]
ChEMBL	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	B	9.24	pKi	0.58	nM	Ki	Eur. J. Med. Chem. (2014) 78: 10-22 [PMID:24675176]
ChEMBL	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	B	9.24	pKi	0.58	nM	Ki	Eur. J. Med. Chem. (2012) 56: 348-360 [PMID:22926225]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	B	9.24	pKi	0.58	nM	Ki	J. Med. Chem. (2008) 51: 5813-5822 [PMID:18800769]
ChEMBL	Binding affinity to rat cloned 5HT7 receptor	B	9.24	pKi	0.58	nM	Ki	J. Med. Chem. (2012) 55: 6375-6380 [PMID:22738316]
ChEMBL	Binding affinity to rat 5HT7 receptor	B	9.24	pKi	0.58	nM	Ki	Bioorg. Med. Chem. (2014) 22: 1736-1750 [PMID:24508140]
GtoPdb	-	-	9.24	pKi	0.58	nM	Ki	J Med Chem (2008) 51: 5813-22 [PMID:18800769]
Serotonin 7 (5-HT7) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5494] [UniProtKB: P50407]
ChEMBL	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	F	6.22	pEC50	600	nM	EC50	J. Med. Chem. (2008) 51: 5813-5822 [PMID:18800769]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Binding affinity to sigma 1 receptor (unknown origin) by radioligand binding assay	B	5.3	pKi	>5000	nM	Ki	Bioorg. Med. Chem. Lett. (2013) 23: 6083-6086 [PMID:24100077]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]