ChEMBL ligand: CHEMBL243954
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969] 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] Serotonin 7 (5-HT7) receptor in Guinea pig [ChEMBL: CHEMBL5494] [UniProtKB: P50407] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Displacement of [3H]spiroperidol from human recombinant Dopamine D2 long receptor	B	6.65	pKi	224	nM	Ki	J Med Chem (2007) 50: 4214-4221 [PMID:17649988]
GtoPdb	-	-	6.65	pKi	224	nM	Ki	J Med Chem (2007) 50: 4214-21 [PMID:17649988]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells	B	7.22	pKi	60.9	nM	Ki	J Med Chem (2007) 50: 4214-4221 [PMID:17649988]
GtoPdb	-	-	7.22	pKi	60.9	nM	Ki	J Med Chem (2007) 50: 4214-21 [PMID:17649988]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb	-	-	5.83	pKi	1464	nM	Ki	J Med Chem (2007) 50: 4214-21 [PMID:17649988]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL	Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley cortex membrane	B	5.83	pKi	1464	nM	Ki	J Med Chem (2007) 50: 4214-4221 [PMID:17649988]
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969]
GtoPdb	-	-	9.89	pKi	0.13	nM	Ki	J Med Chem (2007) 50: 4214-21 [PMID:17649988]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	B	9.89	pKi	0.13	nM	Ki	J Med Chem (2007) 50: 4214-4221 [PMID:17649988]
Serotonin 7 (5-HT7) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5494] [UniProtKB: P50407]
ChEMBL	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	F	5.75	pEC50	1770	nM	EC50	J Med Chem (2007) 50: 4214-4221 [PMID:17649988]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]