ChEMBL ligand: CHEMBL69257
D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!
Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	Compound was evaluated for its ability to displace [3H]spiperone binding from Dopamine receptor D2 in rat striatum.	B	6.98	pKi	104.71	nM	Ki	J Med Chem (1999) 42: 533-535 [PMID:10052959]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Compound was evaluated for its ability to displace [3H]8-OH-DPAT binding from human 5-hydroxytryptamine 1A receptor in mammalian cells	B	6.77	pKi	169.82	nM	Ki	J Med Chem (1999) 42: 533-535 [PMID:10052959]
ChEMBL	Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	B	6.77	pKi	169	nM	Ki	Eur J Med Chem (2014) 85: 716-726 [PMID:25128671]
ChEMBL	Antagonist activity at 5-HT1A receptor (unknown origin)	B	6.77	pKi	169	nM	Ki	Eur J Med Chem (2019) 183: 111705-111705 [PMID:31581003]
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL	Compound was evaluated for its ability to displace [3H]GR-113808 binding from 5-hydroxytryptamine 4 receptor in guinea pig striatum.	B	6	pKi	<1000	nM	Ki	J Med Chem (1999) 42: 533-535 [PMID:10052959]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL	Compound was evaluated for its ability to displace [3H]LSD binding from human recombinant 5-hydroxytryptamine 6 receptor	B	6.28	pKi	524.81	nM	Ki	J Med Chem (1999) 42: 533-535 [PMID:10052959]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL	Binding affinity to 5HT7 receptor	B	8.48	pKi	3.31	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1118-1123 [PMID:20022748]
ChEMBL	Binding affinity to 5-HT7 receptor (unknown origin)	B	8.67	pKi	2.14	nM	Ki	J Med Chem (2018) 61: 8475-8503 [PMID:29767995]
ChEMBL	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	B	8.67	pKi	2.14	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2418-2421 [PMID:29910079]
ChEMBL	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	B	8.67	pKi	2.14	nM	Ki	Eur J Med Chem (2014) 85: 716-726 [PMID:25128671]
ChEMBL	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	B	8.67	pKi	2.14	nM	Ki	Bioorg Med Chem (2012) 20: 1545-1556 [PMID:22277589]
ChEMBL	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	B	8.67	pKi	2.14	nM	Ki	J Med Chem (2002) 45: 2197-2206 [PMID:12014957]
ChEMBL	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	B	8.67	pKi	2.14	nM	Ki	J Med Chem (1999) 42: 533-535 [PMID:10052959]
ChEMBL	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	B	8.67	pKi	2.14	nM	Ki	Bioorg Med Chem Lett (2003) 13: 61-64 [PMID:12467617]
ChEMBL	Antagonist activity at 5-HT7 receptor (unknown origin)	B	8.67	pKi	2.13	nM	Ki	Eur J Med Chem (2019) 183: 111705-111705 [PMID:31581003]
ChEMBL	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	B	8.68	pKi	2.1	nM	Ki	Bioorg Med Chem Lett (2002) 12: 2451-2454 [PMID:12161155]
ChEMBL	Binding affinity towards human 5-hydroxytryptamine 7 receptor	B	8.7	pKi	2	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
GtoPdb	-	-	8.7	pKi	2	nM	Ki	J Med Chem (1999) 42: 533-5 [PMID:10052959]; J Med Chem (2003) 46: 2795-812 [PMID:12825922]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	B	8.7	pKi	2	nM	Ki	J Med Chem (2000) 43: 342-345 [PMID:10669560]
ChEMBL	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	B	8.7	pKi	2	nM	Ki	J Med Chem (2003) 46: 5638-5650 [PMID:14667218]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	B	7.3	pKi	50.12	nM	Ki	J Med Chem (2003) 46: 5638-5650 [PMID:14667218]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]