ChEMBL ligand: CHEMBL487387 (L-(S)-Stepholidine, L-Stepholidine, (-)-Stepholidine)
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] There should be some charts here, you may need to enable JavaScript!
coagulation factor III, tissue factor/Coagulation factor III in Human [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] D3 receptor/Dopamine D3 receptor in Rat [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] There should be some charts here, you may need to enable JavaScript!
D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!
D5 receptor/Dopamine D5 receptor in Human [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL	Displacement of [125I]-BE2254 from Wistar rat alpha1A adrenoceptor after 20 mins	B	5.65	pKi	2238.72	nM	Ki	J Med Chem (2016) 59: 9489-9502 [PMID:27709945]
coagulation factor III, tissue factor/Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726]
ChEMBL	Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs	B	6.98	pIC50	104.58	nM	IC50	Bioorg Med Chem (2013) 21: 62-69 [PMID:23199480]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	B	7.91	pKi	12.29	nM	Ki	Bioorg Med Chem (2014) 22: 5838-5846 [PMID:25308766]
ChEMBL	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	B	8.21	pKi	6.23	nM	Ki	Bioorg Med Chem (2012) 20: 4862-4871 [PMID:22748706]
ChEMBL	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	B	8.23	pKi	5.9	nM	Ki	Bioorg Med Chem (2009) 17: 6898-6907 [PMID:19744859]
ChEMBL	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	B	8.23	pKi	5.9	nM	Ki	Eur J Med Chem (2017) 125: 255-268 [PMID:27688181]
ChEMBL	Displacement of [3H]SCH-23390 from human dopamine D1 receptor assessed as inhibition constant	B	8.23	pKi	5.9	nM	Ki	J Med Chem (2023) 66: 10060-10079 [PMID:37421373]
ChEMBL	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	B	8.47	pKi	3.4	nM	Ki	Bioorg Med Chem (2013) 21: 856-868 [PMID:23332346]
ChEMBL	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	B	7.91	pIC50	12.29	nM	IC50	Bioorg Med Chem (2012) 20: 4862-4871 [PMID:22748706]
ChEMBL	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	F	7.64	pEC50	23	nM	EC50	Bioorg Med Chem (2014) 22: 5838-5846 [PMID:25308766]
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL	Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity	F	4.39	pEC50	41100	nM	EC50	Bioorg Med Chem (2012) 20: 4862-4871 [PMID:22748706]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells by scintillation counting	B	6.01	pKi	974	nM	Ki	Bioorg Med Chem (2009) 17: 6898-6907 [PMID:19744859]
ChEMBL	Displacement of [3H]N-methylspiperone from human dopamine D2 receptor assessed as inhibition constant	B	6.01	pKi	974	nM	Ki	J Med Chem (2023) 66: 10060-10079 [PMID:37421373]
ChEMBL	Displacement of [3H]Spiperone from D2 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	B	6.98	pKi	105.41	nM	Ki	Bioorg Med Chem (2014) 22: 5838-5846 [PMID:25308766]
ChEMBL	Displacement of [3H]Spiprone from human dopamine D2 receptor expressed in HEK293 cells	B	7.25	pKi	56.17	nM	Ki	Bioorg Med Chem (2012) 20: 4862-4871 [PMID:22748706]
GtoPdb	-	-	7.94	pKi	11.6	nM	Ki	Psychopharmacology (Berl.) (2015) 232: 917-30 [PMID:25231919]
ChEMBL	Displacement of [3H]spiperone from dopamine D2 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2013) 21: 856-868 [PMID:23332346]
ChEMBL	Antagonist activity at D2 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of quinpirole	F	5.36	pIC50	4380	nM	IC50	Bioorg Med Chem (2014) 22: 5838-5846 [PMID:25308766]
ChEMBL	Displacement of [3H]Spiprone from human dopamine D2 receptor expressed in HEK293 cells	B	6.98	pIC50	105.41	nM	IC50	Bioorg Med Chem (2012) 20: 4862-4871 [PMID:22748706]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL	Displacement of [3H]Spiperone from D3 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	B	7.05	pKi	90.02	nM	Ki	Bioorg Med Chem (2014) 22: 5838-5846 [PMID:25308766]
ChEMBL	Binding affinity to dopamine D3 receptor (unknown origin) by PDSP assay	B	7.52	pKi	30	nM	Ki	Bioorg Med Chem (2016) 24: 2060-2071 [PMID:27032890]
ChEMBL	Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	B	7.52	pKi	30	nM	Ki	Eur J Med Chem (2017) 125: 255-268 [PMID:27688181]
ChEMBL	Displacement of [3H]N-methylspiperone from human dopamine D3 receptor assessed as inhibition constant	B	7.52	pKi	30	nM	Ki	J Med Chem (2023) 66: 10060-10079 [PMID:37421373]
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
ChEMBL	Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in CHO cells by scintillation counting	B	7.52	pKi	30	nM	Ki	Bioorg Med Chem (2009) 17: 6898-6907 [PMID:19744859]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL	Displacement of [3H]spiperone from human dopamine D4 receptor expressed in CHO cells by scintillation counting	B	5.43	pKi	3748	nM	Ki	Bioorg Med Chem (2009) 17: 6898-6907 [PMID:19744859]
D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918]
ChEMBL	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	B	8.36	pKi	4.4	nM	Ki	Bioorg Med Chem (2009) 17: 6898-6907 [PMID:19744859]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Displacement of [3H]8-OH-DPAT from 5-HT1A receptor (unknown origin) expressed in HEK293 cells by liquid scintillation counter	B	5.3	pKi	>5000	nM	Ki	Bioorg Med Chem (2013) 21: 856-868 [PMID:23332346]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]