ChEMBL ligand: CHEMBL239767 (SB-225002)
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
CXCR1/Interleukin-8 receptor A in Human [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024] There should be some charts here, you may need to enable JavaScript!
CXCR2/Interleukin-8 receptor B in Human [ChEMBL: CHEMBL2434] [GtoPdb: 69] [UniProtKB: P25025] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate	B	6.21	pIC50	612.5	nM	IC50	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
CXCR1/Interleukin-8 receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024]
ChEMBL	Binding affinity to CXCR1	B	5.52	pIC50	>3000	nM	IC50	J Med Chem (2012) 55: 9363-9392 [PMID:22931505]
ChEMBL	Antagonist activity at CXCR1 assessed as inhibition of CXCL8 binding by cell based assay	B	7.66	pIC50	22	nM	IC50	J Med Chem (2012) 55: 9363-9392 [PMID:22931505]
CXCR2/Interleukin-8 receptor B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2434] [GtoPdb: 69] [UniProtKB: P25025]
ChEMBL	Antagonist activity against CXCR2 (unknown origin) by calcium flux assay	F	6.7	pIC50	197.5	nM	IC50	Eur J Med Chem (2021) 226: 113812-113812 [PMID:34536673]
ChEMBL	Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based calcium flux assay	F	7.4	pIC50	40	nM	IC50	J Med Chem (2014) 57: 8378-8397 [PMID:25254640]
ChEMBL	Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assay	F	7.52	pIC50	30	nM	IC50	J Med Chem (2014) 57: 8378-8397 [PMID:25254640]
ChEMBL	Displacement of [125I]IL8 from human recombinant CXCR2 expressed in CHO cells	B	7.66	pIC50	22	nM	IC50	Bioorg Med Chem Lett (2007) 17: 1713-1717 [PMID:17236763]
ChEMBL	Binding affinity to CXCR2	B	7.66	pIC50	22	nM	IC50	J Med Chem (2012) 55: 9363-9392 [PMID:22931505]
ChEMBL	Displacement of 125I-IL-8 from CXCR2 (unknown origin) expressed in CHO cell membrane incubated for 1 hr by liquid scintillation counter analysis	B	7.66	pIC50	22	nM	IC50	Eur J Med Chem (2023) 250: 115175-115175 [PMID:36780833]
GtoPdb	-	-	7.7	pIC50	19.9	nM	IC50	J Biol Chem (1998) 273: 10095-8 [PMID:9553055]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]