ChEMBL ligand: CHEMBL1237044 (Amanda, CG-315E, E-265, ETS-6103, ETS6103, Tramadol, U-26255A, Ultracet, Ultram)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] There should be some charts here, you may need to enable JavaScript!
NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells	B	8.03	pKi	9.4	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	Displacement of the delta antagonist naltrindole from the delta receptor expressed in CHO cells.	-	8.03	pKi	9.4	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-8 [PMID:19027293]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb	Displacement of the kappa agonist U69593 from the kappa receptor expressed in CHO cells.	-	7.85	pKi	14	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2289-94 [PMID:19282177]
ChEMBL	Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells	B	7.85	pKi	14	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Opioid receptor mu 1 agonist activity with monoamine (NE, 5-HT) uptake-blocking activity in the 0.8-1 uM range	F	5.7	pKi	2000	nM	Ki	J Med Chem (1999) 42: 1481-1500 [PMID:10229619]
ChEMBL	Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells	B	5.8	pKi	1600	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	Displacement of the mu aginist peptide DAMGO from the mu receptor expressed in CHO cells.	-	5.8	pKi	1600	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2289-94 [PMID:19282177]
ChEMBL	Inhibition of mu opioid receptor	B	5.12	pIC50	7600	nM	IC50	Bioorg Med Chem Lett (2006) 16: 691-694 [PMID:16257206]
ChEMBL	Binding affinity to mu opioid receptor	B	5.12	pIC50	7600	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1674-1680 [PMID:18242987]
ChEMBL	Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay	F	5.89	pEC50	1300	nM	EC50	ACS Med Chem Lett (2012) 3: 227-231 [PMID:24900459]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Displacement of [3H]-dihydromorphine from mu opioid receptor in rat cerebral cortex by liquid scintillation counting	B	5.62	pKi	2400	nM	Ki	Eur J Med Chem (2011) 46: 4992-4999 [PMID:21864951]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL	Inhibition of NET mediated norepinephrine uptake	B	5.41	pIC50	3861	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1674-1680 [PMID:18242987]
ChEMBL	Inhibition of reuptake of Norepinephrine	B	6.1	pIC50	790	nM	IC50	Bioorg Med Chem Lett (2006) 16: 691-694 [PMID:16257206]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	6.7	pKi	198	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of reuptake of 5HT	B	5.37	pIC50	4300	nM	IC50	Bioorg Med Chem Lett (2006) 16: 691-694 [PMID:16257206]
ChEMBL	Inhibition of SERT mediated 5-hydroxytryptamine uptake	B	5.83	pIC50	1493	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1674-1680 [PMID:18242987]
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	6.43	pIC50	372	nM	IC50	DrugMatrix in vitro pharmacology data
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	B	4.28	pIC50	52500	nM	IC50	J Med Chem (2008) 51: 5932-5942 [PMID:18788725]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]