ChEMBL ligand: CHEMBL1836842
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] There should be some charts here, you may need to enable JavaScript!
protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL	Inhibition of AurB	B	5.65	pIC50	2252	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5870-5875 [PMID:21855335]
protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
ChEMBL	Inhibition of phosphorylation of SAM68 in 293 WT-PTK6 cells after 3 hrs	F	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5870-5875 [PMID:21855335]
ChEMBL	Inhibition of BRK pretreated for 30 mins by microplate reader	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5870-5875 [PMID:21855335]
GtoPdb	-	-	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5870-5 [PMID:21855335]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb	-	-	6.74	pIC50	180	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5870-5 [PMID:21855335]
ChEMBL	Inhibition of LCK	B	6.74	pIC50	180	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5870-5875 [PMID:21855335]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]