ChEMBL ligand: CHEMBL1276848
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] There should be some charts here, you may need to enable JavaScript!
NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6] There should be some charts here, you may need to enable JavaScript!
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955] There should be some charts here, you may need to enable JavaScript!
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL	Inhibition of CHK1	B	4	pIC50	>100000	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]
NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
ChEMBL	Inhibition of NEK1 after 1 hr at room temperature by caliper method	B	6.77	pIC50	170	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]
GtoPdb	-	-	6.77	pIC50	170	nM	IC50	J Med Chem (2010) 53: 7682-98 [PMID:20936789]
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
ChEMBL	Inhibition of NEK2 autophosphorylation after 2 hrs by DELFIA assay	B	6.52	pIC50	300	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]
ChEMBL	Inhibition of NEK2 by microfluidic assay	B	6.64	pIC50	230	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]
GtoPdb	-	-	6.64	pIC50	230	nM	IC50	J Med Chem (2010) 53: 7682-98 [PMID:20936789]
ChEMBL	Inhibition of NEK2 assessed as inhibition of substrate phosphorylation	B	6.7	pIC50	200	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL	Inhibition of PLK1 after 75 mins at room temperature by caliper method	B	4.71	pIC50	19400	nM	IC50	J Med Chem (2010) 53: 7682-7698 [PMID:20936789]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]