compound 2 [PMID: 21627121] [Ligand Id: 8149] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1802381
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  • NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635]
ChEMBL Inhibition of human Cdk1/cyclinB using histone H1 as a substrate and [gamma-32P]ATP B 8 pIC50 10 nM IC50 J Med Chem (2011) 54: 4133-4146 [PMID:21627121]
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
ChEMBL Inhibition of human Nek2 C22V mutant using [gamma-32P] ATP B 4.85 pIC50 14000 nM IC50 J Med Chem (2011) 54: 4133-4146 [PMID:21627121]
GtoPdb - - 8.22 pIC50 <6 nM IC50 J Med Chem (2011) 54: 4133-46 [PMID:21627121]
ChEMBL Inhibition of human Nek2 in using [gamma-32P] ATP B 8.22 pIC50 <6 nM IC50 J Med Chem (2011) 54: 4133-4146 [PMID:21627121]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]