ChEMBL ligand: CHEMBL249317
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239] LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240] There should be some charts here, you may need to enable JavaScript!
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] There should be some charts here, you may need to enable JavaScript!
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] There should be some charts here, you may need to enable JavaScript!
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb	-	-	8.07	pIC50	8.5	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4363-8 [PMID:17600705]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240]
ChEMBL	Inhibition of murine Lck by TR-FRET assay	B	8.07	pIC50	8.5	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4363-4368 [PMID:17600705]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4363-8 [PMID:17600705]
ChEMBL	Inhibition of Lyn	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4363-4368 [PMID:17600705]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL	Inhibition of Syk	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4363-4368 [PMID:17600705]
GtoPdb	-	-	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4363-8 [PMID:17600705]
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
ChEMBL	Inhibition of Txk	B	9.4	pIC50	0.4	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4363-4368 [PMID:17600705]
GtoPdb	-	-	9.4	pIC50	0.4	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4363-8 [PMID:17600705]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]