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ChEMBL ligand: CHEMBL3092863 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 2/CDK2/Cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038469] [GtoPdb: 1973] [UniProtKB: P20248, P24941] | ||||||||
ChEMBL | Inhibition of human recombinant CDK2/cyclin A using [gamma-33P]-ATP after 30 mins by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] | ||||||||
ChEMBL | Inhibition of human recombinant CDK9/cyclin T using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate | B | 5.43 | pIC50 | 3700 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
ChEMBL | Inhibition of human recombinant CDK5/p25 using [gamma-33P]-ATP after 30 mins by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
CDC like kinase 1/Dual specificity protein kinase CLK1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075280] [GtoPdb: 1990] [UniProtKB: P22518] | ||||||||
GtoPdb | - | - | 7.21 | pIC50 | 61 | nM | IC50 | Eur J Med Chem (2013) 62: 728-37 [PMID:23454515] |
ChEMBL | Inhibition of mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 7.21 | pIC50 | 61 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
CDC like kinase 2/Dual specificity protein kinase CLK2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075281] [GtoPdb: 1991] [UniProtKB: O35491] | ||||||||
ChEMBL | Inhibition of mouse recombinant CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 6.68 | pIC50 | 210 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
GtoPdb | - | - | 6.68 | pIC50 | 210 | nM | IC50 | Eur J Med Chem (2013) 62: 728-37 [PMID:23454515] |
CDC like kinase 3/Dual specificity protein kinase CLK3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075282] [GtoPdb: 1992] [UniProtKB: O35492] | ||||||||
ChEMBL | Inhibition of mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 6.26 | pIC50 | 550 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
GtoPdb | - | - | 6.26 | pIC50 | 550 | nM | IC50 | Eur J Med Chem (2013) 62: 728-37 [PMID:23454515] |
CDC like kinase 4/Dual specificity protein kinase CLK4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075283] [GtoPdb: 1993] [UniProtKB: O35493] | ||||||||
GtoPdb | - | - | 7.21 | pIC50 | 61 | nM | IC50 | Eur J Med Chem (2013) 62: 728-37 [PMID:23454515] |
ChEMBL | Inhibition of mouse recombinant CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 7.21 | pIC50 | 61 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
GtoPdb | - | - | 7.55 | pIC50 | 28 | nM | IC50 | Eur J Med Chem (2013) 62: 728-37 [PMID:23454515] |
ChEMBL | Inhibition of human recombinant DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 7.55 | pIC50 | 28 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] | ||||||||
GtoPdb | - | - | 7.14 | pIC50 | 72 | nM | IC50 | Eur J Med Chem (2013) 62: 728-37 [PMID:23454515] |
ChEMBL | Inhibition of human recombinant DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 7.14 | pIC50 | 72 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630] | ||||||||
ChEMBL | Inhibition of human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 6.89 | pIC50 | 130 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
GtoPdb | - | - | 6.89 | pIC50 | 130 | nM | IC50 | Eur J Med Chem (2013) 62: 728-37 [PMID:23454515] |
dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781] | ||||||||
GtoPdb | - | - | 6.74 | pIC50 | 180 | nM | IC50 | Eur J Med Chem (2013) 62: 728-37 [PMID:23454515] |
ChEMBL | Inhibition of human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 6.74 | pIC50 | 180 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]