compound 3b [PMID: 23454515] | Ligand Activity Charts

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compound 3b [PMID: 23454515]
Ligand Activity Charts

compound 3b [PMID: 23454515] [Ligand Id: 8127] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3092863
cyclin dependent kinase 2/CDK2/Cyclin A2 in Human [ChEMBL: CHEMBL3038469] [GtoPdb: 1973] [UniProtKB: P20248, P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 9/CDK9/cyclin T1 in Human [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 1/Dual specificity protein kinase CLK1 in Mouse [ChEMBL: CHEMBL1075280] [GtoPdb: 1990] [UniProtKB: P22518] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 2/Dual specificity protein kinase CLK2 in Mouse [ChEMBL: CHEMBL1075281] [GtoPdb: 1991] [UniProtKB: O35491] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 3/Dual specificity protein kinase CLK3 in Mouse [ChEMBL: CHEMBL1075282] [GtoPdb: 1992] [UniProtKB: O35492] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 4/Dual specificity protein kinase CLK4 in Mouse [ChEMBL: CHEMBL1075283] [GtoPdb: 1993] [UniProtKB: O35493] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 2/CDK2/Cyclin A2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038469] [GtoPdb: 1973] [UniProtKB: P20248, P24941]
ChEMBL	Inhibition of human recombinant CDK2/cyclin A using [gamma-33P]-ATP after 30 mins by scintillation counting	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750]
ChEMBL	Inhibition of human recombinant CDK9/cyclin T using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate	B	5.43	pIC50	3700	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078]
ChEMBL	Inhibition of human recombinant CDK5/p25 using [gamma-33P]-ATP after 30 mins by scintillation counting	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
CDC like kinase 1/Dual specificity protein kinase CLK1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075280] [GtoPdb: 1990] [UniProtKB: P22518]
GtoPdb	-	-	7.21	pIC50	61	nM	IC50	Eur J Med Chem (2013) 62: 728-37 [PMID:23454515]
ChEMBL	Inhibition of mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	7.21	pIC50	61	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075281] [GtoPdb: 1991] [UniProtKB: O35491]
ChEMBL	Inhibition of mouse recombinant CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	6.68	pIC50	210	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
GtoPdb	-	-	6.68	pIC50	210	nM	IC50	Eur J Med Chem (2013) 62: 728-37 [PMID:23454515]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075282] [GtoPdb: 1992] [UniProtKB: O35492]
ChEMBL	Inhibition of mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	6.26	pIC50	550	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
GtoPdb	-	-	6.26	pIC50	550	nM	IC50	Eur J Med Chem (2013) 62: 728-37 [PMID:23454515]
CDC like kinase 4/Dual specificity protein kinase CLK4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075283] [GtoPdb: 1993] [UniProtKB: O35493]
GtoPdb	-	-	7.21	pIC50	61	nM	IC50	Eur J Med Chem (2013) 62: 728-37 [PMID:23454515]
ChEMBL	Inhibition of mouse recombinant CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	7.21	pIC50	61	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
GtoPdb	-	-	7.55	pIC50	28	nM	IC50	Eur J Med Chem (2013) 62: 728-37 [PMID:23454515]
ChEMBL	Inhibition of human recombinant DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	7.55	pIC50	28	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
GtoPdb	-	-	7.14	pIC50	72	nM	IC50	Eur J Med Chem (2013) 62: 728-37 [PMID:23454515]
ChEMBL	Inhibition of human recombinant DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	7.14	pIC50	72	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
ChEMBL	Inhibition of human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	6.89	pIC50	130	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
GtoPdb	-	-	6.89	pIC50	130	nM	IC50	Eur J Med Chem (2013) 62: 728-37 [PMID:23454515]
dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781]
GtoPdb	-	-	6.74	pIC50	180	nM	IC50	Eur J Med Chem (2013) 62: 728-37 [PMID:23454515]
ChEMBL	Inhibition of human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	6.74	pIC50	180	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]