ChEMBL ligand: CHEMBL2070615
testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569] There should be some charts here, you may need to enable JavaScript!
testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53] There should be some charts here, you may need to enable JavaScript!
LIM domain kinase 1 in Human [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] There should be some charts here, you may need to enable JavaScript!
LIM domain kinase 2 in Human [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
GtoPdb	-	-	6.34	pIC50	455	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
ChEMBL	Inhibition of TESK1	B	6.34	pIC50	455	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53]
ChEMBL	Inhibition of TESK2	B	6.6	pIC50	252	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
GtoPdb	-	-	6.6	pIC50	252	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
ChEMBL	Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by RapidFire Mass Spectrometry kinase assay	B	5.64	pIC50	2290.87	nM	IC50	J Med Chem (2022) 65: 13705-13713 [PMID:36205722]
ChEMBL	Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition by NanoBRET assay	B	6.45	pIC50	354.81	nM	IC50	J Med Chem (2022) 65: 13705-13713 [PMID:36205722]
ChEMBL	Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid method	B	7.24	pIC50	58	nM	IC50	Eur J Med Chem (2018) 155: 445-458 [PMID:29908439]
ChEMBL	Inhibition of LIMK1	B	7.24	pIC50	58	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
GtoPdb	-	-	7.24	pIC50	58	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
ChEMBL	Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by RapidFire Mass Spectrometry kinase assay	B	7.25	pIC50	56.23	nM	IC50	J Med Chem (2022) 65: 13705-13713 [PMID:36205722]
ChEMBL	Inhibition of LIMK1 (unknown origin) assessed as ADP formation using cofilin-2 protein as substrate measured after 60 mins incubation with enzyme by Transcreener assay	B	7.27	pIC50	54	nM	IC50	Medchemcomm (2011) 2: 982-986
ChEMBL	Inhibition of LIMK1-catalyzed cofilin phosphorylation in human ZR-75-1 cells	B	9	pIC50	1	nM	IC50	Medchemcomm (2011) 2: 982-986
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671]
ChEMBL	Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by RapidFire Mass Spectrometry kinase assay	B	6.15	pIC50	707.95	nM	IC50	J Med Chem (2022) 65: 13705-13713 [PMID:36205722]
ChEMBL	Inhibition of LIMK2 (unknown origin)	B	6.16	pIC50	696	nM	IC50	Medchemcomm (2011) 2: 982-986
ChEMBL	Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition by NanoBRET assay	B	6.33	pIC50	467.74	nM	IC50	J Med Chem (2022) 65: 13705-13713 [PMID:36205722]
ChEMBL	Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by RapidFire Mass Spectrometry kinase assay	B	6.87	pIC50	134.9	nM	IC50	J Med Chem (2022) 65: 13705-13713 [PMID:36205722]
GtoPdb	-	-	7.42	pIC50	38	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
ChEMBL	Inhibition of LIMK2	B	7.42	pIC50	38	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
ChEMBL	Inhibition of human LIMK1 (312 to 638 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid method	B	7.42	pIC50	38	nM	IC50	Eur J Med Chem (2018) 155: 445-458 [PMID:29908439]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]