ChEMBL ligand: CHEMBL1236539 (7-Hydroxystaurosporine)
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] There should be some charts here, you may need to enable JavaScript!
protein kinase C alpha in Human [GtoPdb: 1482] [UniProtKB: P17252] There should be some charts here, you may need to enable JavaScript!
protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771] There should be some charts here, you may need to enable JavaScript!
protein kinase C gamma in Human [GtoPdb: 1484] [UniProtKB: P05129] There should be some charts here, you may need to enable JavaScript!
protein kinase C delta in Human [GtoPdb: 1485] [UniProtKB: Q05655] There should be some charts here, you may need to enable JavaScript!
protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
3-phosphoinositide dependent protein kinase 1 in Human [GtoPdb: 1519] [UniProtKB: O15530] There should be some charts here, you may need to enable JavaScript!
protein kinase A in Rat [GtoPdb: 1694] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493] There should be some charts here, you may need to enable JavaScript!
checkpoint kinase 2 in Human [GtoPdb: 1988] [UniProtKB: O96017] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta in Human [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!
microtubule affinity regulating kinase 1 in Human [GtoPdb: 2097] [UniProtKB: Q9P0L2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL	Inhibition of CHK1 (unknown origin) using FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide substrate incubated for 1 hr by caliper microfluidic assay	B	8.01	pIC50	9.88	nM	IC50	Eur J Med Chem (2015) 92: 459-470 [PMID:25594740]
GtoPdb	-	-	8.15	pIC50	7	nM	IC50	Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]; Cancer Cell (2007) 11: 175-89 [PMID:17292828]; Cancer Res (2000) 60: 2108-12 [PMID:10786669]
protein kinase C alpha in Human [GtoPdb: 1482] [UniProtKB: P17252]
GtoPdb	-	-	7.54	pIC50	29	nM	IC50	Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414]
protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771]
GtoPdb	-	-	7.54	pIC50	34	nM	IC50	Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414]
protein kinase C gamma in Human [GtoPdb: 1484] [UniProtKB: P05129]
GtoPdb	-	-	7.52	pIC50	30	nM	IC50	Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414]
protein kinase C delta in Human [GtoPdb: 1485] [UniProtKB: Q05655]
GtoPdb	-	-	6.23	pIC50	590	nM	IC50	Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414]
protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156]
GtoPdb	-	-	6.28	pIC50	530	nM	IC50	Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414]
mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539]
GtoPdb	-	-	7.02	pIC50	95	nM	IC50	Cancer Cell (2007) 11: 175-89 [PMID:17292828]
3-phosphoinositide dependent protein kinase 1 in Human [GtoPdb: 1519] [UniProtKB: O15530]
GtoPdb	-	-	7.48	pIC50	33	nM	IC50	Oncogene (2002) 21: 1727-38 [PMID:11896604]
protein kinase A in Rat [GtoPdb: 1694]
GtoPdb	-	-	6	pIC50	1000	nM	IC50	Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb	-	-	7.3	pIC50	50	nM	IC50	Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]
checkpoint kinase 2 in Human [GtoPdb: 1988] [UniProtKB: O96017]
GtoPdb	-	-	5.98	pIC50	1040	nM	IC50	Cancer Res (2000) 60: 2108-12 [PMID:10786669]
glycogen synthase kinase 3 beta in Human [GtoPdb: 2030] [UniProtKB: P49841]
GtoPdb	-	-	6.3	pIC50	500	nM	IC50	Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb	-	-	7.3	pIC50	50	nM	IC50	Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]
microtubule affinity regulating kinase 1 in Human [GtoPdb: 2097] [UniProtKB: Q9P0L2]
GtoPdb	-	-	7.57	pIC50	27	nM	IC50	Cancer Res (2000) 60: 2108-12 [PMID:10786669]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]