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ChEMBL ligand: CHEMBL432713 (TCMDC-139245) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CCR2/C-C chemokine receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597] | ||||||||
ChEMBL | Binding affinity of compound (10 uM) towards H121A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells | B | 5.6 | pKi | 2511.89 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Binding affinity of compound (10 uM) towards Y210A-292A receptor variant (double mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells | B | 5.61 | pKi | 2454.71 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Binding affinity of compound (10 uM) towards H121A/T292A receptor variant (double mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells | B | 5.68 | pKi | 2089.3 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Binding affinity of compound (10 uM) towards T292A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells | B | 6.14 | pKi | 724.44 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Binding affinity of compound (10 uM) towards Y1210A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells | B | 6.25 | pKi | 562.34 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Binding affinity of compound (10 uM) towards D284A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells | B | 6.64 | pKi | 229.09 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Binding affinity of compound (10 uM) towards Q288A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells | B | 6.77 | pKi | 169.82 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Binding affinity of compound (10 uM) towards H121F receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells | B | 6.78 | pKi | 165.96 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Binding affinity of compound (10 uM) towards T290A receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells | B | 6.89 | pKi | 128.82 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
GtoPdb | - | - | 7 | pKi | - | - | - | J Med Chem (2003) 46: 4070-86 [PMID:12954060] |
ChEMBL | Binding affinity to CCR2 (unknown origin) assessed as inhibition constant | B | 7 | pKi | 100 | nM | Ki | J Med Chem (2017) 60: 4735-4779 [PMID:28165741] |
ChEMBL | Binding affinity of compound (10 uM) towards WT receptor variant (mutant C-C chemokine receptor type 2) using radioligand [125I]MCP-1 in HEK 293 cells | B | 7 | pKi | 100 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Binding displacement of [125I]MCP-1 (0.14 nM) was measured on CHO cell membranes expressing human CCR2 (C-C chemokine receptor type 2) | B | 7.3 | pKi | 50.12 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Inhibition of [125I]MCP-1 binding to the cloned C-C chemokine receptor type 2B expressed in CHO cells | B | 7.3 | pKi | 50.12 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
ChEMBL | Antagonist activity at human CCR2 receptor | F | 7.3 | pKi | 50.12 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1450-1456 [PMID:18226895] |
ChEMBL | Displacement of [125I]MCP1 from human CCR2 expressed in CHO cells | B | 7.3 | pKi | 50 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 3735-3739 [PMID:16698264] |
ChEMBL | Antagonist activity at human CCR2 receptor | F | 7.3 | pKi | 50 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1450-1456 [PMID:18226895] |
ChEMBL | Antagonist activity against C-C chemokine receptor type 2 | F | 7.3 | pKi | 50 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1803-1806 [PMID:10969972] |
ChEMBL | Inhibition of [125I]MCP-1 binding to the cloned C-C chemokine receptor type 2B expressed in CHO cells | B | 7.3 | pKi | 50 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
ChEMBL | Binding affinity at C-C chemokine receptor type 2 was determined | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Binding affinity of compound (10 uM) towards Y49F receptor variant (mutant CCR2 receptor) using radioligand [125I]MCP-1 in HEK 293 cells | B | 7.78 | pKi | 16.6 | nM | Ki | J Med Chem (2003) 46: 4070-4086 [PMID:12954060] |
ChEMBL | Inhibition of wild type CCR2 mutant (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2017) 60: 4735-4779 [PMID:28165741] |
CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681] | ||||||||
ChEMBL | Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5 | F | 5.37 | pKi | 4260 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1803-1806 [PMID:10969972] |
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Binding affinity for Dopamine receptor D2 was determined | B | 7.8 | pKi | 15.85 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
ChEMBL | Binding affinity for Dopamine receptor D3 was determined | B | 8.1 | pKi | 7.94 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
ChEMBL | Binding affinity for 5-hydroxytryptamine 1A receptor was determined | B | 7 | pKi | 100 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
ChEMBL | Binding affinity for 5-hydroxytryptamine 1B receptor was determined | B | 7.9 | pKi | 12.59 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566] | ||||||||
ChEMBL | Binding affinity for 5-hydroxytryptamine 1E receptor was determined | B | 8.2 | pKi | 6.31 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939] | ||||||||
ChEMBL | Binding affinity for 5-hydroxytryptamine 1F receptor was determined | B | 8.5 | pKi | 3.16 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
ChEMBL | Binding affinity for 5-hydroxytryptamine 2A receptor was determined | B | 7.7 | pKi | 19.95 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
ChEMBL | Binding affinity for 5-hydroxytryptamine 2B receptor was determined | B | 7.6 | pKi | 25.12 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | Binding affinity for 5-hydroxytryptamine 2C receptor was determined | B | 7.1 | pKi | 79.43 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
ChEMBL | Binding affinity for 5-hydroxytryptamine 6 receptor was determined | B | 7.1 | pKi | 79.43 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
ChEMBL | Binding affinity for 5-hydroxytryptamine 7 receptor was determined | B | 7.2 | pKi | 63.1 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2177-2180 [PMID:11514164] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]