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ChEMBL ligand: CHEMBL20936 (Benzamidine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Acrosin in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243910] [UniProtKB: P08001] | ||||||||
ChEMBL | Reversible competitive inhibition of boar spermatozoa acrosin using BzArgOEt as substrate by Dixon plot analysis | B | 5.4 | pKi | 4000 | nM | Ki | J Med Chem (1978) 21: 1132-1136 [PMID:722718] |
aldehyde oxidase 1/Aldehyde oxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3257] [GtoPdb: 3186] [UniProtKB: Q06278] | ||||||||
ChEMBL | Mixed type inhibition of human AOX assessed as inhibitor dissociation constant by measuring changes in intercept of the double reciprocal plot using phenanthridine as substrate by Michaelis-Menten analysis | B | 2.79 | pKi | 1620 | uM | Kii | J Med Chem (2021) 64: 13025-13037 [PMID:34415167] |
coagulation factor VII/coagulation factor III, tissue factor/Coagulation factor VII/tissue factor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095194] [GtoPdb: 2363, 3192] [UniProtKB: P08709, P13726] | ||||||||
ChEMBL | Inhibition of human soluble tissue factor/factor VIIa expressed in Origami B (DE3) using D-Ile-Pro-Arg-pNA as substrate after 30 mins by spectrophotometric analysis | B | 3.62 | pKi | 240000 | nM | Ki | J Med Chem (2015) 58: 2799-2808 [PMID:25764119] |
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] | ||||||||
ChEMBL | Binding affinity was evaluated against Coagulation factor X | B | 6.39 | pKi | 410 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 1877-1882 [PMID:9873451] |
ChEMBL | Inhibitory concentration against human Coagulation factor Xa (fXa) | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (2002) 45: 1221-1232 [PMID:11881991] |
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
ChEMBL | Binding affinity to thrombin (unknown origin) by displacement titration based isothermal titration colorimetry | B | 3.34 | pKd | 455000 | nM | Kd | J Med Chem (2015) 58: 6960-6971 [PMID:26270568] |
ChEMBL | Binding affinity to thrombin (unknown origin) by direct isothermal titration colorimetry | B | 3.45 | pKd | 355000 | nM | Kd | J Med Chem (2015) 58: 6960-6971 [PMID:26270568] |
ChEMBL | Binding affinity to thrombin (unknown origin) | B | 3.45 | pKd | 355000 | nM | Kd | Medchemcomm (2016) 7: 332-337 |
ChEMBL | Binding affinity to thrombin (unknown origin) | B | 3.59 | pKi | 258000 | nM | Ki | J Med Chem (2015) 58: 6960-6971 [PMID:26270568] |
ChEMBL | Binding affinity against human thrombin | B | 5.91 | pKi | 1240 | nM | Ki | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
ChEMBL | Binding affinity against human thrombin | B | 5.91 | pKi | 1240 | nM | Ki | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
ChEMBL | Inhibitory Activity against human thrombin | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2000) 43: 3033-3044 [PMID:10956211] |
ChEMBL | In vitro binding affinity by measuring the inhibition of human thrombin | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (1994) 37: 3889-3901 [PMID:7966150] |
serine protease 1/Trypsin I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477] | ||||||||
ChEMBL | Binding affinity against trypsin | B | 4.74 | pKd | -4.74 | - | Log Kd | J Med Chem (2002) 45: 2770-2780 [PMID:12061879] |
Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760] | ||||||||
ChEMBL | Inhibitory activity against bovine trypsin expressed as dissociation constant | B | 4.41 | pKi | 39000 | nM | Ki | J Med Chem (1998) 41: 5445-5456 [PMID:9876114] |
ChEMBL | Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5. | B | 4.46 | pKi | 35000 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 1283-1288 |
ChEMBL | Competitive inhibition of bovine beta trypsin using Bz-Arg-NH-Np as substrate at pH 7 at 30 degC | B | 4.49 | pKi | 32000 | nM | Ki | Bioorg Med Chem (2020) 28: 115612-115612 [PMID:32690267] |
ChEMBL | Inhibitory concentration against bovine trypsin | B | 4.7 | pKi | 20000 | nM | Ki | J Med Chem (2002) 45: 1221-1232 [PMID:11881991] |
ChEMBL | Binding affinity against bovine trypsin | B | 4.74 | pKi | 18400 | nM | Ki | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
ChEMBL | Binding affinity against bovine trypsin | B | 4.74 | pKi | 18400 | nM | Ki | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
ChEMBL | In vitro binding affinity by measuring the inhibition of bovine trypsin | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (1994) 37: 3889-3901 [PMID:7966150] |
ChEMBL | Inhibitory Activity against bovine trypsin | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2000) 43: 3033-3044 [PMID:10956211] |
Trypsin II in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4472] [UniProtKB: Q29463] | ||||||||
ChEMBL | log Kd (Binding affinity against specified protein) value of the compound | B | 1.83 | pKd | -1.83 | - | Log Kd | J Med Chem (2002) 45: 2770-2780 [PMID:12061879] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]