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ChEMBL ligand: CHEMBL2431090 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] | ||||||||
ChEMBL | Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs | B | 6.85 | pIC50 | 140 | nM | IC50 | ACS Med Chem Lett (2013) 4: 835-840 [PMID:24900758] |
ChEMBL | Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA | B | 7.59 | pIC50 | 26 | nM | IC50 | ACS Med Chem Lett (2013) 4: 835-840 [PMID:24900758] |
GtoPdb | Assayed using recombinant BRD4-BD1. | - | 7.59 | pIC50 | 26 | nM | IC50 | ACS Med Chem Lett (2013) 4: 835-40 [PMID:24900758] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]