ChEMBL ligand: CHEMBL1828986
bromodomain containing 2/Bromodomain-containing protein 2 in Human [ChEMBL: CHEMBL1293289] [GtoPdb: 1944] [UniProtKB: P25440] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 4/Bromodomain-containing protein 4 in Human [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] There should be some charts here, you may need to enable JavaScript!
CREB binding protein/CREB-binding protein in Human [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
bromodomain containing 2/Bromodomain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293289] [GtoPdb: 1944] [UniProtKB: P25440]
ChEMBL	Displacement of H4Ac4 peptide from first bromodomain of human BRD2 by peptide displacement assay	B	5.8	pIC50	1600	nM	IC50	J Med Chem (2011) 54: 6761-6770 [PMID:21851057]
GtoPdb	Inhibition of binding to recombinant BRD2-BD1.	-	5.8	pIC50	1600	nM	IC50	J Med Chem (2011) 54: 6761-70 [PMID:21851057]
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
ChEMBL	Displacement of H4Ac4 peptide from first bromodomain of human BRD4 by peptide displacement assay	B	5.32	pIC50	4800	nM	IC50	J Med Chem (2011) 54: 6761-6770 [PMID:21851057]
ChEMBL	Binding affinity to human BRD4 bromodomain 1 using H4Ac4 peptide by amplified luminescent proximity homogeneous assay	B	5.32	pIC50	4800	nM	IC50	J Med Chem (2013) 56: 3217-3227 [PMID:23517011]
ChEMBL	Binding affinity to human BRD4 bromodomain 1 using H4Ac4 peptide by amplified luminescent proximity homogeneous assay	B	5.32	pIC50	4786.3	nM	IC50	J Med Chem (2013) 56: 3217-3227 [PMID:23517011]
GtoPdb	Inhibition of binding to recombinant BRD4-BD1.	-	5.32	pIC50	4800	nM	IC50	J Med Chem (2011) 54: 6761-70 [PMID:21851057]
CREB binding protein/CREB-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
ChEMBL	Displacement of H3K56Ac from human CREBBP by peptide displacement assay	B	4.55	pIC50	28100	nM	IC50	J Med Chem (2011) 54: 6761-6770 [PMID:21851057]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]