ChEMBL ligand: CHEMBL2153434 (GW841819X)
ATPase family AAA domain containing 2/ATPase family AAA domain-containing protein 2 in Human [ChEMBL: CHEMBL2150837] [GtoPdb: 2719] [UniProtKB: Q6PL18] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 2/Bromodomain-containing protein 2 in Human [ChEMBL: CHEMBL1293289] [GtoPdb: 1944] [UniProtKB: P25440] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 3/Bromodomain-containing protein 3 in Human [ChEMBL: CHEMBL1795186] [GtoPdb: 2725] [UniProtKB: Q15059] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 4/Bromodomain-containing protein 4 in Human [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] There should be some charts here, you may need to enable JavaScript!
CREB binding protein/CREB-binding protein in Human [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ATPase family AAA domain containing 2/ATPase family AAA domain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150837] [GtoPdb: 2719] [UniProtKB: Q6PL18]
ChEMBL	Binding affinity to ATAD2 by isothermal titration calorimetric analysis	B	4.3	pKd	>50000	nM	Kd	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
bromodomain containing 2/Bromodomain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293289] [GtoPdb: 1944] [UniProtKB: P25440]
ChEMBL	Binding affinity to human Brd2 containing bromodomain BD1 expressed in Escherichia coli assessed as dissociation constant at 25 degC by surface plasma resonance	B	6.66	pKd	220	nM	Kd	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
ChEMBL	Binding affinity to human Brd2 containing bromodomain BD2 expressed in Escherichia coli assessed as dissociation constant at 25 degC by surface plasma resonance	B	7.27	pKd	54	nM	Kd	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
ChEMBL	Binding affinity to N-terminal portion of human Brd2 containing bromodomain BD2 expressed in Escherichia coli at 26 degC by isothermal titration calorimetric analysis	B	7.28	pKd	52.5	nM	Kd	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
ChEMBL	Binding affinity to N-terminal portion of human Brd2 containing bromodomain BD12 expressed in Escherichia coli at 26 degC by isothermal titration calorimetric analysis	B	7.28	pKd	52	nM	Kd	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
ChEMBL	Binding affinity to N-terminal portion of human Brd2 containing bromodomain BD1 expressed in Escherichia coli at 16 degC by isothermal titration calorimetric analysis	B	7.34	pKd	46	nM	Kd	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
ChEMBL	Binding affinity to N-terminal portion of human Brd2 containing bromodomain BD12 expressed in Escherichia coli by isothermal titration calorimetric analysis	B	7.72	pKd	19	nM	Kd	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
ChEMBL	Binding affinity to His6-tagged BRD2 (unknown origin) after 60 mins by fluorescence anisotropy binding Assay	B	5.9	pIC50	1258.93	nM	IC50	J Med Chem (2013) 56: 7501-7515 [PMID:24015967]
GtoPdb	Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD2.	-	7.52	pIC50	29.9	nM	IC50	J Med Chem (2011) 54: 3827-38 [PMID:21568322]
ChEMBL	Displacement of tetra-acetylated H4 peptide from human Brd2 bromodomain BD12 after 1 hr by FRET analysis	B	7.52	pIC50	29.9	nM	IC50	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
bromodomain containing 3/Bromodomain-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795186] [GtoPdb: 2725] [UniProtKB: Q15059]
ChEMBL	Binding affinity to N-terminal portion of human Brd3 containing bromodomain BD12 expressed in Escherichia coli by isothermal titration calorimetric analysis	B	7.72	pKd	19	nM	Kd	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
ChEMBL	Binding affinity to His6-tagged BRD3 (unknown origin) after 60 mins by fluorescence anisotropy binding Assay	B	6.2	pIC50	630.96	nM	IC50	J Med Chem (2013) 56: 7501-7515 [PMID:24015967]
ChEMBL	Displacement of tetra-acetylated H4 peptide from human Brd3 bromodomain BD12 after 1 hr by FRET analysis	B	7.55	pIC50	28.4	nM	IC50	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
GtoPdb	Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD3.	-	7.55	pIC50	28.4	nM	IC50	J Med Chem (2011) 54: 3827-38 [PMID:21568322]
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
ChEMBL	Binding affinity to N-terminal portion of human Brd4 containing bromodomain BD12 expressed in Escherichia coli by isothermal titration calorimetric analysis	B	7.72	pKd	19	nM	Kd	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
ChEMBL	Binding affinity to His6-tagged BRD4 (unknown origin) after 60 mins by fluorescence anisotropy binding Assay	B	6.3	pIC50	501.19	nM	IC50	J Med Chem (2013) 56: 7501-7515 [PMID:24015967]
ChEMBL	Inhibition of tetra-acetylated Histone H4 peptide binding to recombinant human His-tagged BRD4 (1 to 477 residues) after 1 hr by FRET assay	B	6.3	pIC50	501	nM	IC50	J Med Chem (2017) 60: 4533-4558 [PMID:28195723]
ChEMBL	Displacement of tetra-acetylated H4 peptide from human Brd4 bromodomain BD12 after 1 hr by FRET analysis	B	7.81	pIC50	15.5	nM	IC50	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]
GtoPdb	Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD4.	-	7.81	pIC50	15.5	nM	IC50	J Med Chem (2011) 54: 3827-38 [PMID:21568322]
ChEMBL	Inhibition of BRD4 in human HepG2 cells assessed as upregulation of ApoA1 by luciferase reporter gene assay	B	6.36	pEC50	440	nM	EC50	J Med Chem (2017) 60: 4533-4558 [PMID:28195723]
CREB binding protein/CREB-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
ChEMBL	Binding affinity to CREBBP by isothermal titration calorimetric analysis	B	4.3	pKd	>50000	nM	Kd	J Med Chem (2011) 54: 3827-3838 [PMID:21568322]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]