ChEMBL ligand: CHEMBL1201776 (BN-200, BN 200 (BASE), CG-5503, CG5503, CG5503 (BASE), CG5503 IR, NSC-759619, Tapentadol)
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] There should be some charts here, you may need to enable JavaScript!
NET in Human [GtoPdb: 926] [UniProtKB: P23975] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK-293 cells by scintillation counting	B	6.8	pKi	160	nM	Ki	ACS Med Chem Lett (2012) 3: 227-231 [PMID:24900459]
GtoPdb	-	-	6.8	pKi	160	nM	Ki	J Pharmacol Exp Ther (2007) 323: 265-76 [PMID:17656655]
ChEMBL	Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay	F	6.17	pEC50	670	nM	EC50	ACS Med Chem Lett (2012) 3: 227-231 [PMID:24900459]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis	B	4.66	pIC50	21890	nM	IC50	J Med Chem (2019) 62: 9890-9905 [PMID:31597043]
NET in Human [GtoPdb: 926] [UniProtKB: P23975]
GtoPdb	-	-	5.06	pKi	8800	nM	Ki	J Pharmacol Exp Ther (2007) 323: 265-76 [PMID:17656655]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]