ChEMBL ligand: CHEMBL201945
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
NOP receptor/Nociceptin receptor in Human [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] NOP receptor/Nociceptin receptor in Mouse [ChEMBL: CHEMBL3621] [GtoPdb: 320] [UniProtKB: P35377] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells	B	5.6	pIC50	2500	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells	B	5.17	pIC50	6700	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146]
ChEMBL	Displacement of [3H]N/OFQ from human recombinant NOP receptor expressed in CHO cells	B	9.62	pKi	0.24	nM	Ki	Bioorg Med Chem (2009) 17: 5080-5095 [PMID:19527931]
GtoPdb	-	-	9.62	pKi	0.24	nM	Ki	Eur J Pharmacol (2009) 614: 50-7 [PMID:19445927]
ChEMBL	Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells	B	9.57	pIC50	0.27	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
ChEMBL	Antagonist activity on nociceptin-induced [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells	F	9.82	pIC50	0.15	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
GtoPdb	-	-	10	pIC50	0.1	nM	IC50	Eur J Pharmacol (2009) 614: 50-7 [PMID:19445927]; J Med Chem (2006) 49: 847-9 [PMID:16451050]
ChEMBL	Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells	F	6	pEC50	>1000	nM	EC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
NOP receptor/Nociceptin receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621] [GtoPdb: 320] [UniProtKB: P35377]
ChEMBL	Antagonist activity at nociceptin receptor in Swiss mouse vas deferens assessed as inhibition of electrically evoked twitches	F	8.24	pKd	5.75	nM	Kd	Bioorg Med Chem (2009) 17: 5080-5095 [PMID:19527931]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]