tolazoline [Ligand Id: 7310] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL770 (NSC-35110, Priscoline, Tolazine, Tolazolina, Tolazoline) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT trifluoroacetate as radioligand | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1998) 41: 2243-2251 [PMID:9632357] |
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1B receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4697-4699 [PMID:15324890] |
| 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1998) 41: 2243-2251 [PMID:9632357] |
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1D receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4697-4699 [PMID:15324890] |
| TA1 receptor/Trace amine-associated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0] | ||||||||
| ChEMBL | Displacement of (S)-4-(2,4-difluorophenyl-3-tritio) -4,5-dihydro-2-oxazolamine from human TAAR1 receptor expressed in HEK293 cells after 90 mins by beta counting analysis | B | 5.79 | pKi | 1640 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 5244-5248 [PMID:22795332] |
| α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
| GtoPdb | Inhibition of agonist-stimulated [35S]GTPγS binding | - | 6.7 | pKi | 199 | nM | Ki | Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427] |
| α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
| GtoPdb | Inhibition of agonist-stimulated [35S]GTPγS binding | - | 5.5 | pKi | 3162 | nM | Ki | Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427] |
| α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825] | ||||||||
| GtoPdb | Inhibition of agonist-stimulated [35S]GTPγS binding | - | 5.43 | pKi | 3715 | nM | Ki | Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
