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ChEMBL ligand: CHEMBL8618 (NAN-190) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
ChEMBL | Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 657-664 [PMID:15664832] |
ChEMBL | Displacement of [125]HEAT from human adrenergic alpha-1a receptor expressed in CHO cells | B | 9.59 | pKi | 0.26 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 1646-1650 [PMID:17254786] |
GtoPdb | - | - | 10.1 | pKi | - | - | - | Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121] |
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
ChEMBL | Displacement of [125]HEAT from human adrenergic alpha-1b receptor expressed in CHO cells | B | 9.02 | pKi | 0.96 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 1646-1650 [PMID:17254786] |
GtoPdb | - | - | 9.2 | pKi | - | - | - | Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121] |
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] | ||||||||
GtoPdb | - | - | 9.2 | pKi | - | - | - | Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121] |
ChEMBL | Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 1646-1650 [PMID:17254786] |
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
ChEMBL | Compound was evaluated for binding affinity against Dopamine receptor D2 using [3H]raclopride as a radioligand | B | 7.19 | pKi | 64 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 689-694 |
ChEMBL | Binding affinity towards dopamine receptor D2 using [3H]-raclopride radioligand. | B | 7.19 | pKi | 64 | nM | Ki | J Med Chem (1996) 39: 4439-4450 [PMID:8893838] |
ChEMBL | In vitro binding affinity towards Dopamine receptor D2 in rat striatum was determined using [3H]spiperone as radioligand | B | 7.5 | pKi | 31.62 | nM | Ki | J Med Chem (1995) 38: 4044-4055 [PMID:7562940] |
ChEMBL | In vitro ability to inhibit binding of radioligand [3H]spiroperidol to dopamine D2 receptor in rat striatal membranes | B | 8.02 | pKi | 9.55 | nM | Ki | J Med Chem (1994) 37: 99-104 [PMID:8289207] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
ChEMBL | Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry | B | 7.06 | pKi | 87 | nM | Ki | Eur J Med Chem (2014) 85: 716-726 [PMID:25128671] |
ChEMBL | Displacement of [3H]-8-OH-DPAT from human 5-HT1A expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay | B | 8.35 | pKi | 4.49 | nM | Ki | Eur J Med Chem (2020) 199: 112395-112395 [PMID:32442850] |
ChEMBL | Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells after 120 mins | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (2009) 52: 7892-7896 [PMID:19705871] |
GtoPdb | - | - | 9.4 | pKi | - | - | - | Eur J Pharmacol (1998) 355: 245-56 [PMID:9760039] |
ChEMBL | Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay | F | 8.3 | pIC50 | 5 | nM | IC50 | Eur J Med Chem (2017) 137: 108-116 [PMID:28575721] |
ChEMBL | Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay | F | 8.33 | pIC50 | 4.73 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 2039-2049 [PMID:29730027] |
ChEMBL | Antagonist activity at human recombinant 5-HT1A receptor expressed in CHOK1 cells incubated for 25 mins followed by addition of methiothepin by microbeta2 scintillation counter | B | 8.95 | pIC50 | 1.12 | nM | IC50 | Bioorg Med Chem (2019) 27: 4163-4173 [PMID:31383628] |
ChEMBL | Antagonist activity at human recombinant 5-HT1A receptor expressed in CHOK1 cells incubated for 25 mins followed by addition of methiothepin by microbeta2 scintillation counter | B | 8.96 | pIC50 | 1.1 | nM | IC50 | Bioorg Med Chem (2019) 27: 4163-4173 [PMID:31383628] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
ChEMBL | In vitro ability to inhibit binding of radioligand [3H]8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex | B | 8.88 | pKi | 1.32 | nM | Ki | J Med Chem (1994) 37: 99-104 [PMID:8289207] |
ChEMBL | In vitro ability to displace [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex. | B | 8.9 | pKi | 1.26 | nM | Ki | J Med Chem (1995) 38: 1273-1277 [PMID:7731013] |
ChEMBL | Binding affinity at 5-hydroxytryptamine 1A receptor | B | 9.15 | pKi | 0.71 | nM | Ki | J Med Chem (1995) 38: 4044-4055 [PMID:7562940] |
ChEMBL | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1996) 39: 126-134 [PMID:8568799] |
ChEMBL | In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement. | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1998) 41: 157-166 [PMID:9457239] |
ChEMBL | In vitro binding affinity to 5-hydroxytryptamine 1A receptor using [125I](R)-(+)-trans-8-OH-PIPAT as radioligand in rat hippocampal homogenate | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1994) 37: 4572-4575 [PMID:7799409] |
ChEMBL | Binding affinity towards 5-hydroxytryptamine 1A receptor using 0.1 nM [3H]-8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tet-ralin), from rat hippocampal homogenate | B | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 2467-2472 [PMID:9873563] |
ChEMBL | Binding affinity towards 5-hydroxytryptamine 1A receptor of rat hippocampus using [3H]-8-hydroxy-2-(di-n-propylamine) tetralin (8-OH-DPAT) as a radioligand | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1991) 34: 2633-2638 [PMID:1652026] |
ChEMBL | Binding affinity towards rat 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT radioligand. | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1996) 39: 4439-4450 [PMID:8893838] |
ChEMBL | Binding affinity towards 5-hydroxytryptamine 1A receptor in the rat brain (hippocampus) using [3H]8-OH-DPAT | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1996) 39: 1125-1129 [PMID:8676348] |
ChEMBL | Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]OH-DPAT displacement. | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1989) 32: 1921-1926 [PMID:2754715] |
ChEMBL | Inhibition of binding of [125I]8-OH-PIPAT ligand to 5-hydroxytryptamine 1A receptor of rat hippocampal homogenates | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1994) 37: 1406-1407 [PMID:8182697] |
ChEMBL | In vitro ability to displace the radioligand [3H]-OH-DPAT from binding to rat 5-hydroxytryptamine 1A receptor | B | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5863-5866 [PMID:15501057] |
ChEMBL | Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1988) 31: 1968-1971 [PMID:3172131] |
ChEMBL | Binding affinity at 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes by [3H]8-OH-DPAT displacement. | B | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 689-694 |
ChEMBL | Binding affinity at 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes by [3H]8-OH-DPAT displacement. | B | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 689-694 |
ChEMBL | Ability to displace [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor | B | 9.26 | pKi | 0.55 | nM | Ki | J Med Chem (1999) 42: 4952-4960 [PMID:10585205] |
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] | ||||||||
ChEMBL | Binding affinity at 5-hydroxytryptamine 1B receptor | B | 5.97 | pKi | 1071.52 | nM | Ki | J Med Chem (1995) 38: 4044-4055 [PMID:7562940] |
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
ChEMBL | Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry | B | 9.22 | pKi | 0.6 | nM | Ki | Eur J Med Chem (2014) 85: 716-726 [PMID:25128671] |
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] | ||||||||
ChEMBL | In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor | B | 7.06 | pKi | 87 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5863-5866 [PMID:15501057] |
5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939] | ||||||||
GtoPdb | - | - | 6.7 | pKi | - | - | - | Proc Natl Acad Sci USA (1993) 90: 408-12 [PMID:8380639] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]