ChEMBL ligand: CHEMBL2393130 (Apabetalone, RVX-000222, RVX000222, RVX-208)
bromodomain containing 2/Bromodomain-containing protein 2 in Human [ChEMBL: CHEMBL1293289] [GtoPdb: 1944] [UniProtKB: P25440] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 3/Bromodomain-containing protein 3 in Human [ChEMBL: CHEMBL1795186] [GtoPdb: 2725] [UniProtKB: Q15059] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 4/Bromodomain-containing protein 4 in Human [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] There should be some charts here, you may need to enable JavaScript!
bromodomain testis associated/Bromodomain testis-specific protein in Human [ChEMBL: CHEMBL1795185] [GtoPdb: 2729] [UniProtKB: Q58F21] There should be some charts here, you may need to enable JavaScript!
CREB binding protein/CREB-binding protein in Human [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
bromodomain containing 2/Bromodomain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293289] [GtoPdb: 1944] [UniProtKB: P25440]
ChEMBL	Binding affinity to human BRD2 bromodomain 1 by isothermal titration calorimetry	B	4.77	pKd	16900	nM	Kd	J Med Chem (2016) 59: 1492-1500 [PMID:26367539]
ChEMBL	Inhibition of human 6x-His-tagged BRD2 bromodomain 1 expressed in Escherichia coli	B	5.24	pKd	5800	nM	Kd	J Med Chem (2018) 61: 9316-9334 [PMID:30253095]
ChEMBL	Binding affinity to human BRD2 bromodomain 1 expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetry	B	5.24	pKd	5800	nM	Kd	J Med Chem (2016) 59: 1492-1500 [PMID:26367539]
ChEMBL	Binding affinity to recombinant BRD2 BD1 (unknown origin) incubated for 1 hr by TR-FRET assay	B	5.24	pKd	5780	nM	Kd	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Inhibition of recombinant human His6-tagged BRD2 bromodomain 1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells	B	5.24	pKd	5780	nM	Kd	J Med Chem (2017) 60: 4533-4558 [PMID:28195723]
ChEMBL	Binding affinity to recombinant BRD2 BD2 (unknown origin) incubated for 1 hr by TR-FRET assay	B	6.6	pKd	251	nM	Kd	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Inhibition of recombinant human His6-tagged BRD2 bromodomain 2 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells	B	6.6	pKd	251	nM	Kd	J Med Chem (2017) 60: 4533-4558 [PMID:28195723]
ChEMBL	Inhibition of human 6x-His-tagged BRD2 bromodomain 2 expressed in Escherichia coli	B	6.6	pKd	250	nM	Kd	J Med Chem (2018) 61: 9316-9334 [PMID:30253095]
ChEMBL	Binding affinity to human BRD2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetry	B	6.6	pKd	250	nM	Kd	J Med Chem (2016) 59: 1492-1500 [PMID:26367539]
ChEMBL	Binding affinity to human BRD2 bromodomain 2 by isothermal titration calorimetry	B	6.69	pKd	206	nM	Kd	J Med Chem (2016) 59: 1492-1500 [PMID:26367539]
ChEMBL	Inhibition of BRD2 BD1 (unknown origin) after 1 hr by TR-FRET assay	B	5.24	pIC50	5780	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Binding affinity BRD2 BD1 (unknown origin) incubated for 1 hr by TR-FRET assay	B	5.24	pIC50	5697	nM	IC50	J Med Chem (2022) 65: 2388-2408 [PMID:34982556]
ChEMBL	Inhibition of BRD2 BD2 (unknown origin) after 1 hr by TR-FRET assay	B	6.6	pIC50	251	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Binding affinity BRD2 BD2 (unknown origin) incubated for 1 hr by TR-FRET assay	B	6.61	pIC50	246	nM	IC50	J Med Chem (2022) 65: 2388-2408 [PMID:34982556]
GtoPdb	Measured using a TR-FRET assay to evaluate binding to BD2 of BRD2.	-	7.05	pIC50	90	nM	IC50	PLoS ONE (2013) 8: e83190 [PMID:24391744]
bromodomain containing 3/Bromodomain-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795186] [GtoPdb: 2725] [UniProtKB: Q15059]
ChEMBL	Inhibition of recombinant human His6-tagged BRD3 bromodomain 1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells	B	5.39	pKd	4065	nM	Kd	J Med Chem (2017) 60: 4533-4558 [PMID:28195723]
ChEMBL	Binding affinity to human BRD3 BD2 by ITC method	B	5.4	pKd	4000	nM	Kd	J Med Chem (2018) 61: 4317-4334 [PMID:29656650]
ChEMBL	Inhibition of human 6x-His-tagged BRD3 bromodomain 1 expressed in Escherichia coli	B	5.4	pKd	4000	nM	Kd	J Med Chem (2018) 61: 9316-9334 [PMID:30253095]
ChEMBL	Binding affinity to recombinant BRD3 BD1 (unknown origin) incubated for 1 hr by TR-FRET assay	B	5.4	pKd	3962	nM	Kd	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Binding affinity to recombinant BRD3 BD2 (unknown origin) incubated for 1 hr by TR-FRET assay	B	6.69	pKd	203	nM	Kd	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Inhibition of recombinant human His6-tagged BRD3 bromodomain 2 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells	B	6.71	pKd	195	nM	Kd	J Med Chem (2017) 60: 4533-4558 [PMID:28195723]
ChEMBL	Inhibition of human 6x-His-tagged BRD3 bromodomain 2 expressed in Escherichia coli	B	6.72	pKd	190	nM	Kd	J Med Chem (2018) 61: 9316-9334 [PMID:30253095]
GtoPdb	AlphaScreen data for bromodomain 1 of BRD3.	-	4.06	pIC50	87000	nM	IC50	Proc Natl Acad Sci USA (2013) 110: 19754-9 [PMID:24248379]
ChEMBL	Displacement of tetra-acetylated histone H4 peptide from recombinant human His-tagged BRD3 BD1 expressed in bacterial expression system by alphascreen assay	B	4.06	pIC50	87000	nM	IC50	J Med Chem (2019) 62: 11080-11107 [PMID:31789032]
ChEMBL	Binding affinity to BRD3 BD1 (unknown origin) by alphascreen assay	B	4.06	pIC50	87000	nM	IC50	Eur J Med Chem (2021) 226: 113853-113853 [PMID:34547507]
GtoPdb	AlphaScreen data assessing the bromodomain 2 domain of BRD3.	-	5.31	pIC50	4900	nM	IC50	Proc Natl Acad Sci USA (2013) 110: 19754-9 [PMID:24248379]
ChEMBL	Inhibition of BRD3 BD1 (unknown origin) after 1 hr by TR-FRET assay	B	5.4	pIC50	3962	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Binding affinity BRD3 BD1 (unknown origin) incubated for 1 hr by TR-FRET assay	B	5.41	pIC50	3878	nM	IC50	J Med Chem (2022) 65: 2388-2408 [PMID:34982556]
ChEMBL	Binding affinity to BRD3 BD2 (unknown origin) by alphascreen assay	B	6.29	pIC50	510	nM	IC50	Eur J Med Chem (2021) 226: 113853-113853 [PMID:34547507]
ChEMBL	Displacement of tetra-acetylated histone H4 peptide from recombinant human His-tagged BRD3 BD2 expressed in bacterial expression system by alphascreen assay	B	6.29	pIC50	510	nM	IC50	J Med Chem (2019) 62: 11080-11107 [PMID:31789032]
ChEMBL	Inhibition of human His-tagged BRD3 bromodomain 2 using biotin-H4K5acK8acK12acK16ac as substrate incubated for 30 mins by alphascreen assay	B	6.29	pIC50	510	nM	IC50	J Med Chem (2016) 59: 1565-1579 [PMID:26731490]
GtoPdb	Measured using a TR-FRET assay to evaluate binding to BD2 of BRD3.	-	6.55	pIC50	280	nM	IC50	PLoS ONE (2013) 8: e83190 [PMID:24391744]
ChEMBL	Binding affinity BRD3 BD2 (unknown origin) incubated for 1 hr by TR-FRET assay	B	6.66	pIC50	217	nM	IC50	J Med Chem (2022) 65: 2388-2408 [PMID:34982556]
ChEMBL	Inhibition of BRD3 BD2 (unknown origin) after 1 hr by TR-FRET assay	B	6.69	pIC50	203	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
ChEMBL	Binding affinity to human BRD4 bromodomain 1 by isothermal titration calorimetry	B	5.05	pKd	8930	nM	Kd	J Med Chem (2016) 59: 1492-1500 [PMID:26367539]
ChEMBL	Inhibition of BRD4-BD1 (unknown origin) assessed as dissociation constant by ITC method	B	5.39	pKd	4100	nM	Kd	J Med Chem (2022) 65: 5660-5674 [PMID:35348328]
ChEMBL	Inhibition of recombinant human His6-tagged BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells preincubated for 30 mins followed by H4K5acK8acK12acK16ac peptide substrate addition after 30 mins by alphascreen assay	B	5.94	pKd	1142	nM	Kd	J Med Chem (2017) 60: 4533-4558 [PMID:28195723]
ChEMBL	Binding affinity to human BRD4 BD1 by isothermal calorimetry analysis	B	5.94	pKd	1142	nM	Kd	J Med Chem (2020) 63: 5585-5623 [PMID:32324999]
ChEMBL	Binding affinity to BRD4 BD1 (unknown origin) by isothermal titration calorimetry	B	5.94	pKd	1142	nM	Kd	Eur J Med Chem (2022) 227: 113953-113953 [PMID:34731760]
ChEMBL	Binding affinity to human BRD4 BD1 assessed as dissociation constant by ITC analysis	B	5.94	pKd	1142	nM	Kd	Eur J Med Chem (2022) 238: 114423-114423 [PMID:35544982]
ChEMBL	Binding affinity to recombinant BRD4 BD1 (unknown origin) incubated for 1 hr by TR-FRET assay	B	5.94	pKd	1142	nM	Kd	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Binding affinity to human BRD4 bromodomain 1 expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetry	B	5.96	pKd	1100	nM	Kd	J Med Chem (2016) 59: 1492-1500 [PMID:26367539]
ChEMBL	Inhibition of human 6x-His-tagged BRD4 bromodomain 1 expressed in Escherichia coli	B	5.96	pKd	1100	nM	Kd	J Med Chem (2018) 61: 9316-9334 [PMID:30253095]
ChEMBL	Binding affinity to BRD4 bromodomain 1 (unknown origin) by isothermal titration calorimetric analysis	B	5.96	pKd	1100	nM	Kd	J Med Chem (2016) 59: 1271-1298 [PMID:26572217]
ChEMBL	Binding affinity to human BRD4 bromodomain 2 by isothermal titration calorimetry	B	6.52	pKd	303	nM	Kd	J Med Chem (2016) 59: 1492-1500 [PMID:26367539]
ChEMBL	Inhibition of BRD4-BD2 (unknown origin) assessed as dissociation constant by ITC method	B	6.7	pKd	200	nM	Kd	J Med Chem (2022) 65: 5660-5674 [PMID:35348328]
ChEMBL	Binding affinity to BRD4 bromodomain 2 (unknown origin) by isothermal titration calorimetric analysis	B	6.85	pKd	140	nM	Kd	J Med Chem (2016) 59: 1271-1298 [PMID:26572217]
ChEMBL	Binding affinity to human BRD4 bromodomain 2 expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetry	B	6.85	pKd	140	nM	Kd	J Med Chem (2016) 59: 1492-1500 [PMID:26367539]
ChEMBL	Binding affinity to BRD4 BD2 (unknown origin)	B	6.87	pKd	135	nM	Kd	Eur J Med Chem (2021) 213: 113137-113137 [PMID:33460833]
ChEMBL	Inhibition of recombinant human His6-tagged BRD4 bromodomain 2 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells preincubated for 30 mins followed by HSGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH peptide substrate addition after 30 mins by alphascreen assay	B	6.87	pKd	135	nM	Kd	J Med Chem (2017) 60: 4533-4558 [PMID:28195723]
ChEMBL	Binding affinity to human BRD4 BD2 by isothermal calorimetry analysis	B	6.87	pKd	135	nM	Kd	J Med Chem (2020) 63: 5585-5623 [PMID:32324999]
ChEMBL	Binding affinity to recombinant BRD4 BD2 (unknown origin) incubated for 1 hr by TR-FRET assay	B	6.87	pKd	135	nM	Kd	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Binding affinity to N-terminal His-tagged BRD4 BD2 (unknown origin) by isothermal calorimetric titration assay	B	6.87	pKd	135	nM	Kd	J Med Chem (2020) 63: 9070-9092 [PMID:32691591]
ChEMBL	Binding affinity to human BRD4 BD2 assessed as dissociation constant by ITC analysis	B	6.87	pKd	135	nM	Kd	Eur J Med Chem (2022) 238: 114423-114423 [PMID:35544982]
ChEMBL	Binding affinity to BRD4 BD2 (unknown origin) by isothermal titration calorimetry	B	6.87	pKd	135	nM	Kd	Eur J Med Chem (2022) 227: 113953-113953 [PMID:34731760]
ChEMBL	Inhibition of human 6x-His-tagged BRD4 bromodomain 2 expressed in Escherichia coli	B	6.89	pKd	130	nM	Kd	J Med Chem (2018) 61: 9316-9334 [PMID:30253095]
ChEMBL	Inhibition of BRD4 (unknown origin)	B	4.9	pIC50	12700	nM	IC50	Eur J Med Chem (2022) 230: 114094-114094 [PMID:34998039]
ChEMBL	Inhibition of human His-tagged BRD4 BD1 (49 to 170 residues) using H-SGRGK(Ac)GGK(Ac)GLGK-(Ac)GGAK(Ac)RHRK(Biotin)-OH as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by TR-FRET assay	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2016) 121: 294-299 [PMID:27266999]
ChEMBL	Inhibition of His/thioredoxin-tagged human recombinant BRD4 bromodomain-1 (43 to 166 residues) expressed in Escherichia coli BL21 Star (DE3) pre-incubated for 30 mins followed by biotinylated histone peptide H4 addition measured after 30 mins by AlphaScreen assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2017) 60: 9990-10012 [PMID:29172540]
ChEMBL	Displacement of (+)-JQ1 from 6H-Thr BRD4 Y390A mutant BD1 (unknown origin) after 30 mins by TR-FRET assay	B	5.2	pIC50	6309.57	nM	IC50	J Med Chem (2018) 61: 4317-4334 [PMID:29656650]
ChEMBL	Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced IL-8 RNA expression preincubated for 24 hrs followed by poly(I:C) addition and measured after 4 hrs by SYBR green dye-based qRT-PCR analysis	B	5.41	pIC50	3850	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced grobeta RNA expression preincubated for 24 hrs followed by poly(I:C) addition and measured after 4 hrs by SYBR green dye-based qRT-PCR analysis	B	5.43	pIC50	3730	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Inhibition of BRD4 in poly(I:C)-stimulated human SAECs TLR3-inducible IL-6 gene expression pre-incubated for 24 hrs before poly(I:C) stimulation for 4 hrs by qRT-PCR analysis	B	5.48	pIC50	3290	nM	IC50	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Inhibition of biotinylated H4 K5,8,12,16Ac peptide binding to GST-tagged BRD4 bromodomain1 (unknown origin) measured after 60 mins by AlphaScreen assay	B	5.51	pIC50	3100	nM	IC50	Bioorg Med Chem (2019) 27: 1871-1881 [PMID:30926312]
ChEMBL	Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG56 RNA expression preincubated for 24 hrs followed by poly(I:C) addition and measured after 4 hrs by SYBR green dye-based qRT-PCR analysis	B	5.56	pIC50	2740	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG54 RNA expression preincubated for 24 hrs followed by poly(I:C) addition and measured after 4 hrs by SYBR green dye-based qRT-PCR analysis	B	5.58	pIC50	2630	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Inhibition of GST-tagged BRD4 bromodomain (unknown origin) using biotinylated histone H4KAc peptide (1 to 21 residues) as substrate by HTRF assay	B	5.61	pIC50	2450	nM	IC50	J Med Chem (2020) 63: 3678-3700 [PMID:32153186]
ChEMBL	Inhibition of human BRD4 bromo domain 1	B	5.7	pIC50	1985	nM	IC50	Bioorg Med Chem Lett (2017) 27: 4051-4055 [PMID:28765013]
ChEMBL	Displacement of tetra-acetylated histone H4 peptide from recombinant human N-terminal His-tagged BRD4 BD1 incubated for 2 hrs by TR-FRET assay	B	5.74	pIC50	1800	nM	IC50	J Med Chem (2019) 62: 11080-11107 [PMID:31789032]
ChEMBL	Inhibition of BRD4 in poly(I:C)-stimulated human SAECs TLR3-inducible CIG5 gene expression pre-incubated for 24 hrs before poly(I:C) stimulation for 4 hrs by qRT-PCR analysis	B	5.78	pIC50	1660	nM	IC50	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Displacement of (+)-JQ1 from 6H-Thr BRD4 Y97A mutant BD2 (unknown origin) after 30 mins by TR-FRET assay	B	5.8	pIC50	1584.89	nM	IC50	J Med Chem (2018) 61: 4317-4334 [PMID:29656650]
ChEMBL	Binding affinity recombinant human BRD4 BD1 (42 to 168 residues) expressed in Escherichia coli BL21(DE3) incubated for 1 hr by TR-FRET assay	B	5.94	pIC50	1151	nM	IC50	J Med Chem (2022) 65: 2388-2408 [PMID:34982556]
ChEMBL	Inhibition of BRD4 BD1 (unknown origin) after 1 hr by TR-FRET assay	B	5.94	pIC50	1142	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Inhibition of BRD4 bromodomain-1 (unknown origin) by europium based LANCE TR-FRET assay	B	6.19	pIC50	645	nM	IC50	Bioorg Med Chem (2015) 23: 953-959 [PMID:25678016]
ChEMBL	Inhibition of human BRD4 BD2 (342 to 460 residues) at 30 uM preincubated for 30 mins followed by substrate addition measured after 30 mins by TR-FRET assay	B	6.21	pIC50	610	nM	IC50	Eur J Med Chem (2016) 121: 294-299 [PMID:27266999]
ChEMBL	Inhibition of human BRD4 bromodomain2 by Alphascreen assay	B	6.29	pIC50	510	nM	IC50	Bioorg Med Chem Lett (2017) 27: 4051-4055 [PMID:28765013]
ChEMBL	Inhibition of recombinant full length human N-terminal His6-tagged BRD4 (2 to 1362 residues) expressed in baculovirus infected insect cells using histone H4 peptide as substrate by alpha screen assay	B	6.29	pIC50	510	nM	IC50	Eur J Med Chem (2019) 163: 281-294 [PMID:30529546]
ChEMBL	Inhibition of human recombinant N-terminal 6his-tagged BRD4 bromodomain 2 expressed in Escherichia coli BL21(DE3) using using H4 peptide as substrate by alphascreen assay	B	6.29	pIC50	510	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126577-126577 [PMID:31421967]
ChEMBL	Inhibition of BRD4 (unknown origin)	B	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2020) 186: 111852-111852 [PMID:31759729]
ChEMBL	Inhibition of BRD4 BD2 (unknown origin) after 1 hr by TR-FRET assay	B	6.87	pIC50	135	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Binding affinity human BRD4 BD2 incubated for 1 hr by TR-FRET assay	B	6.88	pIC50	132	nM	IC50	J Med Chem (2022) 65: 2388-2408 [PMID:34982556]
ChEMBL	Inhibition of biotinylated H4 K5,8,12,16Ac peptide binding to GST-tagged BRD4 bromodomain2 (unknown origin) measured after 60 mins by AlphaScreen assay	B	7	pIC50	100	nM	IC50	Bioorg Med Chem (2019) 27: 1871-1881 [PMID:30926312]
ChEMBL	Inhibition of human BRD4 bromo domain 2	B	7.17	pIC50	67	nM	IC50	Bioorg Med Chem Lett (2017) 27: 4051-4055 [PMID:28765013]
ChEMBL	Inhibition of BRD4 bromodomain 2 (unknown origin) incubated for 30 mins by ELISA	B	7.36	pIC50	43.8	nM	IC50	Bioorg Med Chem Lett (2019) 29: 2168-2172 [PMID:31257080]
ChEMBL	Displacement of tetra-acetylated histone H4 peptide from recombinant human N-terminal His-tagged BRD4 BD2 incubated for 2 hrs by TR-FRET assay	B	7.4	pIC50	40	nM	IC50	J Med Chem (2019) 62: 11080-11107 [PMID:31789032]
GtoPdb	Measured using a TR-FRET assay to evaluate binding to BD2 of BRD4.	-	7.4	pIC50	40	nM	IC50	PLoS ONE (2013) 8: e83190 [PMID:24391744]
bromodomain testis associated/Bromodomain testis-specific protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795185] [GtoPdb: 2729] [UniProtKB: Q58F21]
ChEMBL	Binding affinity to recombinant BRDT BD1 (unknown origin) incubated for 1 hr by TR-FRET assay	B	5.32	pKd	4836	nM	Kd	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Binding affinity to recombinant BRDT BD2 (unknown origin) incubated for 1 hr by TR-FRET assay	B	6.15	pKd	708	nM	Kd	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Binding affinity BRDT BD1 (unknown origin) incubated for 1 hr by TR-FRET assay	B	5.3	pIC50	5027	nM	IC50	J Med Chem (2022) 65: 2388-2408 [PMID:34982556]
ChEMBL	Inhibition of BRDT BD1 (unknown origin) after 1 hr by TR-FRET assay	B	5.32	pIC50	4836	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Inhibition of BRDT BD2 (unknown origin) after 1 hr by TR-FRET assay	B	6.15	pIC50	708	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Binding affinity BRDT BD2 (unknown origin) incubated for 1 hr by TR-FRET assay	B	6.16	pIC50	696	nM	IC50	J Med Chem (2022) 65: 2388-2408 [PMID:34982556]
CREB binding protein/CREB-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
ChEMBL	Binding affinity to recombinant CBP (unknown origin) incubated for 1 hr by TR-FRET assay	B	5	pKd	>10000	nM	Kd	J Med Chem (2020) 63: 5242-5256 [PMID:32255647]
ChEMBL	Inhibition of CBP (unknown origin) after 1 hr by TR-FRET assay	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2018) 151: 450-461 [PMID:29649741]
ChEMBL	Binding affinity CBP (unknown origin) incubated for 1 hr by TR-FRET assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2022) 65: 2388-2408 [PMID:34982556]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate	B	5.77	pIC50	1689	nM	IC50	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]