FR191413 [Ligand Id: 669] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL329762 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411] | ||||||||
| ChEMBL | Agonist activity at bradykinin B2 receptor (unknown origin) | B | 9.16 | pIC50 | 0.69 | nM | IC50 | Eur J Med Chem (2021) 210: 112948-112948 [PMID:33139111] |
| ChEMBL | Inhibition of [3H]BK (1.0 nM) binding to the human bradykinin receptor B2, expressed in CHO cells | B | 9.17 | pIC50 | 0.68 | nM | IC50 | J Med Chem (2004) 47: 2853-2863 [PMID:15139763] |
| GtoPdb | - | - | 9.2 | pIC50 | - | - | - | J Med Chem (2004) 47: 2853-63 [PMID:15139763] |
| Bradykinin B2 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4111] [UniProtKB: O70526] | ||||||||
| ChEMBL | Concentration required to inhibit specific binding of [3H]-BK(0.06 nM) to the bradykinin receptor B2 | B | 8.2 | pIC50 | 6.3 | nM | IC50 | J Med Chem (2004) 47: 2853-2863 [PMID:15139763] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
