odanacatib [Ligand Id: 6478] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL481611 (MK-0822, MK0822, Odanacatib) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibition of cathepsin B in human HepG2 cells | B | 5.98 | pIC50 | 1050 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| ChEMBL | Inhibition of cathepsin B | B | 5.99 | pIC50 | 1034 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin F/Cathepsin F in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2517] [GtoPdb: 2347] [UniProtKB: Q9UBX1] | ||||||||
| ChEMBL | Inhibition of cathepsin F | B | 6.1 | pIC50 | 795 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin H/Cathepsin H in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2225] [GtoPdb: 2349] [UniProtKB: P09668] | ||||||||
| ChEMBL | Inhibition of cathepsin H | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] | ||||||||
| ChEMBL | Inhibition of human cathepsin K | B | 9.74 | pKi | 0.18 | nM | Ki | Eur J Med Chem (2018) 144: 201-210 [PMID:29272750] |
| ChEMBL | Inhibition of human recombinant CatK assessed as suppression of enzyme-mediated Z-Phe-Arg-AMC cleavage incubated for 1 hrs by QFRET assay | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2012) 55: 6363-6374 [PMID:22742641] |
| ChEMBL | Inhibition of cathepsin-k | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2012) 55: 8827-8837 [PMID:22984809] |
| ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 675-679 [PMID:19117756] |
| ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 887-892 [PMID:20061146] |
| ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 920-923 [PMID:21232956] |
| ChEMBL | Inhibition of cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | J Med Chem (2010) 53: 4332-4353 [PMID:20218623] |
| ChEMBL | Inhibition of human cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| GtoPdb | - | - | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-8 [PMID:18226527] |
| Cathepsin K in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3349] [UniProtKB: P43236] | ||||||||
| ChEMBL | Inhibition of rabbit cathepsin K | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] | ||||||||
| ChEMBL | Inhibition of Cathepsin L (unknown origin) using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition by fluorescence based analysis | B | 5.9 | pKi | 1258.93 | nM | Ki | Bioorg Med Chem (2019) 27: 115083-115083 [PMID:31561938] |
| ChEMBL | Inhibition of cathepsin L in human HepG2 cells | B | 5.31 | pIC50 | 4843 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| ChEMBL | Inhibition of cathepsin L | B | 5.52 | pIC50 | 2995 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin V/Cathepsin L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3272] [GtoPdb: 2352] [UniProtKB: O60911] | ||||||||
| ChEMBL | Inhibition of cathepsin V | B | 6.12 | pIC50 | 762 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774] | ||||||||
| ChEMBL | Inhibition of human recombinant CatS assessed as suppression of enzyme-mediated Z-Val-Val-Arg-AMC cleavage by QFRET assay | B | 6.74 | pIC50 | 183 | nM | IC50 | J Med Chem (2012) 55: 6363-6374 [PMID:22742641] |
| GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-8 [PMID:18226527] |
| ChEMBL | Inhibition of cathepsin S | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| ChEMBL | Inhibition of cathepsin S in human ramos cells | B | 7.35 | pIC50 | 45 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin Z/Cathepsin Z in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4160] [GtoPdb: 2354] [UniProtKB: Q9UBR2] | ||||||||
| GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-8 [PMID:18226527] |
| ChEMBL | Inhibition of cathepsin Z | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779] | ||||||||
| ChEMBL | Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition by fluorescence based analysis | B | 6.9 | pKi | 125.89 | nM | Ki | Bioorg Med Chem (2019) 27: 115083-115083 [PMID:31561938] |
| cathepsin C/Dipeptidyl peptidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634] | ||||||||
| ChEMBL | Inhibition of cathepsin C | B | 8 | pIC50 | >10 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
