ChEMBL ligand: CHEMBL1644699 (Sodium Hydrogensulfide)
Carbonic anhydrase in Methanosarcina thermophila [ChEMBL: CHEMBL3932] [UniProtKB: P40881] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
ChEMBL	Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL	Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2017) 25: 575-580 [PMID:27914949]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5	B	6.22	pKi	600	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3	B	6.22	pKi	600	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.22	pKi	600	nM	Ki	Bioorg Med Chem Lett (2012) 22: 7142-7145 [PMID:23072866]
ChEMBL	Inhibition of human recombinant wild type CA1 by stopped-flow CO2 hydration method	B	6.22	pKi	600	nM	Ki	Bioorg Med Chem Lett (2013) 23: 256-260 [PMID:23200251]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.22	pKi	600	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1636-1638 [PMID:23414807]
ChEMBL	Inhibition of human carbonic anhydrase-1 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.22	pKi	600	nM	Ki	Bioorg Med Chem (2013) 21: 4472-4476 [PMID:23790722]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.22	pKi	600	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4389-4396 [PMID:25168745]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem Lett (2012) 22: 7142-7145 [PMID:23072866]
ChEMBL	Inhibition of human recombinant wild type CA2 by stopped-flow CO2 hydration method	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem Lett (2013) 23: 256-260 [PMID:23200251]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1636-1638 [PMID:23414807]
ChEMBL	Inhibition of human recombinant CA2 by CO2 hydration assay	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of human carbonic anhydrase-2 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem (2013) 21: 4472-4476 [PMID:23790722]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1127-1132 [PMID:24461298]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4389-4396 [PMID:25168745]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4402-4406 [PMID:25168748]
ChEMBL	Inhibition of human CA2 after 15 mins by stopped-flow/Co2 hydration assay	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL	Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow method	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem (2017) 25: 575-580 [PMID:27914949]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow CO2 hydration method	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem (2017) 25: 2010-2015 [PMID:28238511]
ChEMBL	Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	4.4	pKi	40000	nM	Ki	Bioorg Med Chem (2017) 25: 4800-4804 [PMID:28754318]
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb	Calcium imaging	-	2.9	pEC50	-	-	-	Eur Urol (2008) 53: 391-9 [PMID:18031925]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]