MEL57A [Ligand Id: 6260] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1253475 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| HCN1/Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250401] [GtoPdb: 400] [UniProtKB: O88704] | ||||||||
| ChEMBL | Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay | B | 6.22 | pEC50 | 600 | nM | EC50 | J Med Chem (2010) 53: 6773-6777 [PMID:20795648] |
| GtoPdb | - | - | 6.49 | pEC50 | 320 | nM | EC50 | Br J Pharmacol (2012) 166: 602-16 [PMID:22091830] |
| HCN2/Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250408] [GtoPdb: 401] [UniProtKB: O88703] | ||||||||
| ChEMBL | Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay | B | 4.74 | pEC50 | 18300 | nM | EC50 | J Med Chem (2010) 53: 6773-6777 [PMID:20795648] |
| GtoPdb | - | - | 4.9 | pEC50 | 12560 | nM | EC50 | Br J Pharmacol (2012) 166: 602-16 [PMID:22091830] |
| HCN4 in Human [GtoPdb: 403] [UniProtKB: Q9Y3Q4] | ||||||||
| GtoPdb | - | - | 4.12 | pEC50 | 75260 | nM | EC50 | Br J Pharmacol (2012) 166: 602-16 [PMID:22091830] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
