(S)-UH 301 [Ligand Id: 61] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL22778
  • 5-HT1A receptor/5-hydroxytryptamine receptor 1A in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/5-hydroxytryptamine receptor 1A in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT7 receptor/5-hydroxytryptamine receptor 7 in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
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  • D2 receptor/D(2) dopamine receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • D2 receptor/D(2) dopamine receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor/5-hydroxytryptamine receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to 5HT1A receptor B 7.6 pKd 25.12 nM Kd J Med Chem (2009) 52: 6107-6125 [PMID:19754201]
ChEMBL Binding affinity was measured on cloned Human 5-hydroxytryptamine 1A receptor which is labeled by [3H]8-OH-DPAT B 7.06 pKi 87 nM Ki J Med Chem (2000) 43: 1339-1349 [PMID:10753471]
GtoPdb - - 7.9 pKi 13.5 nM Ki Eur J Pharmacol (1998) 355: 245-56 [PMID:9760039]
5-HT1A receptor/5-hydroxytryptamine receptor 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor sites, in rat striatum membranes using [3H]- sandoz 205-501 as radioligand B 6.4 pKi 400 nM Ki J Med Chem (1990) 33: 1541-1544 [PMID:2140413]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor sites in cortical membranes using [3H]8-OH-DPAT as radioligand B 7.28 pKi 52 nM Ki J Med Chem (1990) 33: 1541-1544 [PMID:2140413]
ChEMBL Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor B 7.28 pKi 52 nM Ki J Med Chem (1997) 40: 1252-1257 [PMID:9111299]
ChEMBL Binding affinity was evaluated against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]8-OH-DPAT as radioligand B 7.34 pKi 46 nM Ki J Med Chem (1998) 41: 2765-2778 [PMID:9667967]
ChEMBL Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor B 7.34 pKi 46 nM Ki J Med Chem (1997) 40: 1252-1257 [PMID:9111299]
ChEMBL Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand B 7.61 pKi 24.8 nM Ki J Med Chem (1996) 39: 4036-4043 [PMID:8831769]
5-HT7 receptor/5-hydroxytryptamine receptor 7 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT B 5.5 pKi 3180 nM Ki J Med Chem (2000) 43: 1339-1349 [PMID:10753471]
D2 receptor/D(2) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity was measured on cloned Human D2A Receptor which is labeled by [3H]raclopride B 5.42 pKi 3760 nM Ki J Med Chem (2000) 43: 1339-1349 [PMID:10753471]
D2 receptor/D(2) dopamine receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Binding affinity was evaluated against Dopamine receptor D2 on rat striatum using [3H]spiperone as radioligand; ND = Not determined B 6.21 pKi 614 nM Ki J Med Chem (1998) 41: 2765-2778 [PMID:9667967]
ChEMBL In vitro radioligand binding assay on Dopamine receptor D2 of rat striatum using [3H]- spiperone B 6.21 pKi 614 nM Ki J Med Chem (1997) 40: 1252-1257 [PMID:9111299]
ChEMBL In vitro radioligand binding assay on Dopamine receptor D2 of rat striatum using [3H]- spiperone B 6.4 pKi 400 nM Ki J Med Chem (1997) 40: 1252-1257 [PMID:9111299]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]