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ChEMBL ligand: CHEMBL101683 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
ChEMBL | Inhibition of Cyclin-dependent kinase 1 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of Epidermal growth factor receptor | B | 5.14 | pIC50 | 7300 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of Met proto-oncogene tyrosine kinase | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313] |
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
ChEMBL | Inhibition of Insulin-like growth factor I receptor | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313] |
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
ChEMBL | Inhibition of Proto-oncogene tyrosine-protein kinase Kit | B | 6.62 | pIC50 | 240 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibition of c-Src tyrosine kinase | B | 5.15 | pIC50 | 7000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313] |
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
ChEMBL | Inhibition of vascular endothelial growth factor receptor 1 | B | 6.74 | pIC50 | 180 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
GtoPdb | - | - | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6003-8 [PMID:17869515] |
ChEMBL | Inhibition of phosphorylated-Kdr after 30 mins | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6003-6008 [PMID:17869515] |
ChEMBL | Inhibition of Vascular endothelial growth factor receptor 2 | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2967-2971 [PMID:12941313] |
ChEMBL | Inhibition of KDR by ELISA | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2939-2943 [PMID:18420406] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]