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ChEMBL ligand: CHEMBL120077 (JNJ-10198409) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
ChEMBL | Inhibitory activity against Casein Kinase 2 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
ChEMBL | Inhibitory activity against CDK1 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Cdk1 | B | 5 | pIC50 | >10000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibitory activity against CDK2 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Cdk2 | B | 5 | pIC50 | >10000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
ChEMBL | Inhibitory activity against CDK4 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Cdk4 | B | 4 | pIC50 | >100000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
ChEMBL | Inhibitory activity against CDK7 | B | 4.25 | pIC50 | 56700 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Cdk7 | B | 5 | pIC50 | >10000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibitory activity against EGFR | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of human EGFR at 10000 nM | B | 4 | pIC50 | >100000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Inhibitory activity against bFGFR1 | B | 4.34 | pIC50 | 45800 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of bFGFR1 | B | 4.34 | pIC50 | 45800 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
ChEMBL | Inhibitory activity against FAK | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibitory activity against IRK | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibitory activity against MAPK | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] | ||||||||
ChEMBL | Inhibitory activity against PDGFRalpha | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of PDGFRalpha | B | 7.35 | pIC50 | 45 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
ChEMBL | Inhibitory activity against PDGFRbeta kinase | B | 8.38 | pIC50 | 4.2 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of PDGFRbeta | B | 8.38 | pIC50 | 4.2 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
GtoPdb | - | - | 8.38 | pIC50 | 4.2 | nM | IC50 | J Med Chem (2005) 48: 8163-73 [PMID:16366598] |
ChEMBL | Antiproliferative activity against PDGF-BB stimulated HCASMC | F | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
ChEMBL | Inhibitory activity against HER2 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of HER2 | B | 5 | pIC50 | >10000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibitory activity against c-ABL | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of cAbl | B | 7.66 | pIC50 | 22 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
ChEMBL | Inhibitory activity against FYN | B | 6.42 | pIC50 | 378 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Fyn | B | 6.42 | pIC50 | 378 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibitory activity against LCK | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of Lck | B | 7 | pIC50 | 100 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibitory activity against c-SRC | B | 6.73 | pIC50 | 185 | nM | IC50 | J Med Chem (2005) 48: 8163-8173 [PMID:16366598] |
ChEMBL | Inhibition of c-Src | B | 6.73 | pIC50 | 185 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]