PI1 [Ligand Id: 5814] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1801361
  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
Created with Highcharts 10.3.3ValuesChart context menuCannabinoid CB1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • NPS receptor/Neuropeptide S receptor in Human [ChEMBL: CHEMBL5162] [GtoPdb: 302] [UniProtKB: Q6W5P4]
Created with Highcharts 10.3.3ValuesChart context menuNeuropeptide S receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Inhibition of CB1 receptor B 5.22 pIC50 6000 nM IC50 Bioorg Med Chem Lett (2010) 20: 4704-4708 [PMID:20615693]
NPS receptor/Neuropeptide S receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5162] [GtoPdb: 302] [UniProtKB: Q6W5P4]
GtoPdb - - 7.3 pIC50 - - - Bioorg Med Chem Lett (2010) 20: 4704-8 [PMID:20615693]
ChEMBL Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay F 7.37 pIC50 43 nM IC50 Bioorg Med Chem Lett (2010) 20: 4704-4708 [PMID:20615693]
ChEMBL Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay F 7.37 pIC50 43 nM IC50 J Med Chem (2013) 56: 9045-9056 [PMID:24171469]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]