SB 414240 [Ligand Id: 5769] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL295770 (SB-414240) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Binding affinity towards human mu-opioid receptors in CHO (Chinese hamster ovary) cell lines | B | 5.7 | pKi | >=2000 | nM | Ki | J Med Chem (2001) 44: 1675-1689 [PMID:11356103] |
| NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] | ||||||||
| GtoPdb | - | - | 9 | pKi | 1 | nM | Ki | J Med Chem (2001) 44: 1675-89 [PMID:11356103] |
| ChEMBL | Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes | B | 9 | pKi | 1 | nM | Ki | J Med Chem (2001) 44: 1675-1689 [PMID:11356103] |
| NK3 receptor/Neurokinin 3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371] | ||||||||
| ChEMBL | Displacement of [125 I]-[MePhe]-NKB binding to hNK-3-CHO (Chinese hamster ovary) membranes | B | 6.71 | pKi | 193 | nM | Ki | J Med Chem (2001) 44: 1675-1689 [PMID:11356103] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
