KF26777 [Ligand Id: 5618] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2181965 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| GtoPdb | - | - | 5.74 | pKi | 1800 | nM | Ki | Eur J Pharmacol (2002) 444: 133-41 [PMID:12063073] |
| ChEMBL | Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter | B | 5.74 | pKi | 1800 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| ChEMBL | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter | B | 6.33 | pKi | 470 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| GtoPdb | - | - | 6.33 | pKi | 470 | nM | Ki | Eur J Pharmacol (2002) 444: 133-41 [PMID:12063073] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| GtoPdb | - | - | 9.7 | pKi | 0.2 | nM | Ki | Eur J Pharmacol (2002) 444: 133-41 [PMID:12063073] |
| ChEMBL | Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay | F | 6.57 | pIC50 | 270 | nM | IC50 | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| GtoPdb | - | - | 6.21 | pKi | 620 | nM | Ki | Eur J Pharmacol (2002) 444: 133-41 [PMID:12063073] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
