ST-1535 [Ligand Id: 5613] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL197669 (Ct-1500, St-1535, St1535, ST-1535)
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
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  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
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  • A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
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  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO-K1 cells after 60 mins B 7 pKi 100 nM Ki J Med Chem (2013) 56: 5456-5463 [PMID:23789814]
ChEMBL Inhibition of human recombinant adenosine A1 receptor B 7.1 pKi 79.2 nM Ki J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
GtoPdb - - 7.14 pKi 71.8 nM Ki J Med Chem (2005) 48: 6887-96 [PMID:16250647]
ChEMBL Binding affinity towards human Adenosine A1 receptor expressed in CHO cells using 1 nM [3H]DPCPX B 7.14 pKi 71.8 nM Ki J Med Chem (2005) 48: 6887-6896 [PMID:16250647]
ChEMBL Antagonist activity at human adenosine A1 receptor assessed as cAMP level by cell based assay F 7.14 pKi 71.8 nM Ki Bioorg Med Chem Lett (2013) 23: 3427-3433 [PMID:23602401]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in HEK293 cells after 1 hr by competitive binding assay B 7.97 pKi 10.7 nM Ki J Med Chem (2013) 56: 5456-5463 [PMID:23789814]
GtoPdb - - 8.18 pKi 6.6 nM Ki J Med Chem (2005) 48: 6887-96 [PMID:16250647]
ChEMBL Binding affinity towards human Adenosine A2a receptor expressed in HEK293 cells using 6 nM [3H]CGS-21680 B 8.18 pKi 6.6 nM Ki J Med Chem (2005) 48: 6887-6896 [PMID:16250647]
ChEMBL Binding affinity to human adenosine A2A receptor B 8.18 pKi 6.6 nM Ki J Med Chem (2008) 51: 4449-4455 [PMID:18637670]
ChEMBL Antagonist activity at human adenosine A2A receptor assessed as cAMP level by cell based assay F 8.18 pKi 6.6 nM Ki Bioorg Med Chem Lett (2013) 23: 3427-3433 [PMID:23602401]
ChEMBL Inhibition of human recombinant adenosine receptor A2a F 8.18 pKi 6.6 nM Ki J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL Antagonist activity at human adenosine A2A receptor expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP accumulation incubated for 10 mins prior to NECA addition F 6.37 pIC50 430 nM IC50 J Med Chem (2013) 56: 5456-5463 [PMID:23789814]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb - - 6.45 pKi 352.3 nM Ki J Med Chem (2005) 48: 6887-96 [PMID:16250647]
ChEMBL Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX B 6.45 pKi 352.3 nM Ki J Med Chem (2005) 48: 6887-6896 [PMID:16250647]
ChEMBL Inhibition of human recombinant adenosine receptor A2b B 6.45 pKi 352 nM Ki J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Inhibition of human recombinant adenosine A3 receptor B 5 pKi >10000 nM Ki J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
GtoPdb - - 6 pKi >1000 nM Ki J Med Chem (2005) 48: 6887-96 [PMID:16250647]
ChEMBL Binding affinity towards human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA B 6 pKi >1000 nM Ki J Med Chem (2005) 48: 6887-6896 [PMID:16250647]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]