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ChEMBL ligand: CHEMBL175543 (MRS-3558, MRS-5358) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
ChEMBL | Inhibition of [3H]R-PIA binding to human Adenosine A1 receptor expressed in CHO cells | B | 6.59 | pKi | 260 | nM | Ki | J Med Chem (2005) 48: 1745-1758 [PMID:15771421] |
ChEMBL | Displacement of radioligand from human adenosine A1 receptor expressed in CHO cells | B | 6.59 | pKi | 260 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
ChEMBL | Displacement of [3H]CCPA form human adenosine A1 receptor expressed in CHO cells | B | 6.59 | pKi | 260 | nM | Ki | Bioorg Med Chem (2008) 16: 8546-8556 [PMID:18752961] |
ChEMBL | Displacement of [3H]R-PIA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by liquid scintillation counting | B | 6.59 | pKi | 260 | nM | Ki | J Med Chem (2012) 55: 4847-4860 [PMID:22559880] |
ChEMBL | Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter | B | 6.59 | pKi | 260 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
GtoPdb | - | - | 6.59 | pKi | 260 | nM | Ki | Nat Rev Drug Discov (2006) 5: 247-64 [PMID:16518376] |
A1 receptor/Adenosine A1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612] | ||||||||
GtoPdb | - | - | 7.8 | pKi | 15.8 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
ChEMBL | Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyl-uronamide from mouse recombinant adenosine A1 receptor expressed in HEK293 cells | B | 7.82 | pKi | 15.3 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
A1 receptor in Rat [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
GtoPdb | - | - | 6.98 | pKi | 105 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
GtoPdb | - | - | 5.63 | pKi | 2330 | nM | Ki | Nat Rev Drug Discov (2006) 5: 247-64 [PMID:16518376] |
ChEMBL | Inhibition of [3H]-CGS- 21680 binding to human Adenosine A2A receptor expressed in CHO cells | B | 5.64 | pKi | 2300 | nM | Ki | J Med Chem (2005) 48: 1745-1758 [PMID:15771421] |
ChEMBL | Displacement of radioligand from human adenosine A2A receptor expressed in HEK293 cells | B | 5.64 | pKi | 2300 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
ChEMBL | Displacement of [3H]R-PIA form human adenosine A2A receptor expressed in HEK cells | B | 5.64 | pKi | 2300 | nM | Ki | Bioorg Med Chem (2008) 16: 8546-8556 [PMID:18752961] |
ChEMBL | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting | B | 5.64 | pKi | 2300 | nM | Ki | J Med Chem (2012) 55: 4847-4860 [PMID:22559880] |
ChEMBL | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter | B | 5.64 | pKi | 2300 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
A2A receptor/Adenosine A2a receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2115] [GtoPdb: 19] [UniProtKB: Q60613] | ||||||||
GtoPdb | - | - | 4.98 | pKi | 10400 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
ChEMBL | Displacement of [3H]2-[p-(2-carboxyethyl)phenyl-ethylamino]-5'-N-ethylcarboxamidoadenosine from mouse recombinant adenosine A2A receptor expressed in HEK293 cells | B | 4.98 | pKi | 10400 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
A2A receptor in Rat [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
GtoPdb | - | - | 5.97 | pKi | 1080 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
GtoPdb | - | - | 5 | pKi | >10000 | nM | Ki | Nat Rev Drug Discov (2006) 5: 247-64 [PMID:16518376] |
ChEMBL | Activation of human adenosine A2B receptor | B | 5 | pEC50 | >=10000 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cells | B | 9.54 | pKi | 0.29 | nM | Ki | J Med Chem (2005) 48: 1745-1758 [PMID:15771421] |
ChEMBL | Displacement of radioligand from human adenosine A3 receptor expressed in CHO cells | B | 9.54 | pKi | 0.29 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
ChEMBL | Displacement of [3H]CGS21680 form human adenosine A3 receptor expressed in CHO cells | B | 9.54 | pKi | 0.29 | nM | Ki | Bioorg Med Chem (2008) 16: 8546-8556 [PMID:18752961] |
ChEMBL | Displacement of [3H]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counting | B | 9.54 | pKi | 0.29 | nM | Ki | J Med Chem (2012) 55: 4847-4860 [PMID:22559880] |
ChEMBL | Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter | B | 9.54 | pKi | 0.29 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
GtoPdb | - | - | 9.54 | pKi | 0.29 | nM | Ki | Nat Rev Drug Discov (2006) 5: 247-64 [PMID:16518376] |
A3 receptor/Adenosine A3 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075269] [GtoPdb: 21] [UniProtKB: Q61618] | ||||||||
ChEMBL | Displacement of [125I]N6-(-amino-3-iodobenzyl)adenosine-5'-N-methyl-uronamide from mouse recombinant adenosine A3 receptor expressed in HEK293 cells | B | 8.83 | pKi | 1.49 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2813-2819 [PMID:18424135] |
GtoPdb | - | - | 8.83 | pKi | 1.49 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
GtoPdb | - | - | 9 | pKi | 1 | nM | Ki | . A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics (2010) |
ChEMBL | Inhibition of [125I]AB-MECA binding to rat Adenosine A3 receptor expressed in CHO cells | B | 9 | pKi | 1 | nM | Ki | J Med Chem (2005) 48: 1745-1758 [PMID:15771421] |
ChEMBL | Displacement of [125I]I-AB-MECA from human rat adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter | B | 9 | pKi | 1 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
ChEMBL | Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay | F | 5.49 | pIC50 | 3260 | nM | IC50 | J Med Chem (2016) 59: 11006-11026 [PMID:27933810] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]