fenoterol [Ligand Id: 557] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL32800 (Airum, Berodual, Berodual n, Berotec, Berotec 100, Berotec 200, Dosberotec, Duovent, Fenoterol, Fenoterol hbr, Fenoterol hydrobromide, NSC-757811, Partusisten, TH-1165, TH 1165A, TH-1165A, TH 1165A [AS HYDROBROMIDE SALT], TH 1165A FREE BASE, TH-1165A FREE BASE) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| GtoPdb | - | - | 5 | pKi | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
| GtoPdb | - | - | 7.5 | pEC50 | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
| ChEMBL | Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation | F | 7.96 | pEC50 | 10.96 | nM | EC50 | Eur J Med Chem (2023) 246: 114961-114961 [PMID:36495629] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Binding affinity to N-terminal FLAG-tagged C-terminal His-10-tagged human beta2 adrenoceptor expressed in insect Sf9 cells by surface plasmon resonance analysis | B | 6.86 | pKd | 139 | nM | Kd | ACS Med Chem Lett (2013) 4: 1005-1010 [PMID:24454993] |
| ChEMBL | Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM | B | 7 | pKd | 100 | nM | Kd | Bioorg Med Chem Lett (2013) 23: 5376-5381 [PMID:23954364] |
| ChEMBL | Displacement of [3H]-CGP12177 from human recombinant beta2 adrenoceptor expressed in HEK293 cells after 1 hr by scintillation counting analysis | B | 6.9 | pKi | 126 | nM | Ki | ACS Med Chem Lett (2013) 4: 1005-1010 [PMID:24454993] |
| GtoPdb | - | - | 7 | pKi | - | - | - |
Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]; ACS Med Chem Lett (2013) 4: 1005-1010 [PMID:24454993]; Br J Pharmacol (2022) 179: 4692-4708 [PMID:35732075]; Mol Pharmacol (2015) 87: 103-20 [PMID:25324048] |
| GtoPdb | - | - | 8.9 | pEC50 | - | - | - |
Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]; Br J Pharmacol (2022) 179: 4692-4708 [PMID:35732075] |
| ChEMBL | Agonist activity at human beta2-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation | F | 9.61 | pEC50 | 0.25 | nM | EC50 | Eur J Med Chem (2023) 246: 114961-114961 [PMID:36495629] |
| Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
| ChEMBL | In vitro inhibitory concentration Beta-2 adrenergic receptor in Guinea pig trachea | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2687-2692 [PMID:12873495] |
| ChEMBL | Agonist activity at adrenergic beta-2 receptor in guinea pig tracheal rings assessed as myorelaxing activity on carbachol-induced contraction in presence of 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one | F | 7.72 | pEC50 | 19 | nM | EC50 | J Med Chem (2007) 50: 5003-5011 [PMID:17845020] |
| ChEMBL | Agonist activity at adrenergic beta-2 receptor in guinea pig tracheal rings assessed as myorelaxing activity on carbachol-induced contraction | F | 7.74 | pEC50 | 18 | nM | EC50 | J Med Chem (2007) 50: 5003-5011 [PMID:17845020] |
| β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
| GtoPdb | - | - | 5.4 | pKi | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
| GtoPdb | - | - | 7.6 | pEC50 | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
| ChEMBL | Agonist activity at human beta3-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation | F | 7.66 | pEC50 | 21.88 | nM | EC50 | Eur J Med Chem (2023) 246: 114961-114961 [PMID:36495629] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
